Factors Associated With Endodontic Flare‐Ups: A Systematic Review and Meta‐Analysis
ABSTRACT Background Endodontic flare‐ups, characterized by severe postoperative pain and/or swelling requiring unscheduled intervention, remain a clinically significant concern in root canal therapy. Identifying the factors associated with flare‐ups is important for anticipating and managing patient outcomes.
Jun Ohshima +8 more
wiley +1 more source
Computational Pharmacodynamic Analysis of Cyclopeptides Derived from c[Trp-Phe-D-Pro-Phe] (CJ-15,208), an Unusual Class of Mixed μ/k-Opioid Receptor Ligands Lacking the Traditional Pharmacophores. [PDF]
Francescato M +4 more
europepmc +1 more source
Production routing decisions in a two‐echelon supply chain with multiple delivery modes
Abstract We study an original two‐echelon production routing problem with multiple delivery modes (2E‐PRP‐MDM). In the first echelon, the primary production facility is tasked with satisfying the demands of two distinct entities: a set of warehouses and a set of customers through direct shipments. In the second echelon, warehouses become delivery hubs,
Rachida Benfedel +2 more
wiley +1 more source
Review of Structural Modification and Development of Novel Tramadol Derivatives. [PDF]
Wang N +5 more
europepmc +1 more source
How and when remote workdays impact employee daily social need fulfilment
Abstract Hybrid working, as a now‐common flexible work arrangement, transforms how employees connect with each other and requires updated theorizing to understand its social implications. Grounded in interaction ritual theory, we examined how and when remote (vs.
Vera M. Schweitzer +5 more
wiley +1 more source
Structural and Pharmacological Characterization of AT-121 Reveals Carbonic Anhydrase Inhibition as a Complementary Mechanism to Dual MOR/NOR Agonism. [PDF]
Bonardi A +4 more
europepmc +1 more source
ABSTRACT Background For older people and those with more comorbidities, kidney replacement therapy may not offer a mortality benefit. Conservative kidney management represents an alternative treatment pathway for kidney failure without dialysis. Objectives To identify the clinical and socioeconomic factors associated with choosing a non‐dialysis care ...
Kerry‐Lee Rosenberg +7 more
wiley +1 more source
Understanding Mechanical Properties of <i>Nothofagus alpina</i> (Poepp. & Endl.) Oerst. Wood Through Controlled Freeze-Heat Treatments: Linking Physical, Chemical, and Structural Changes. [PDF]
Valle R +6 more
europepmc +1 more source
Lucilia sericata larvae secrete bioactive compounds that promote wound debridement and antimicrobial defence in chronic tissue injuries. Achillea sintenisii extract offers phytotherapeutic support, enhancing healing through anti‐inflammatory and regenerative properties. Diabetic Wistar rats were treated topically with Furacin®, larval secretions, plant
Nevra Polat +2 more
wiley +1 more source
Activation dynamics of a water-soluble human mu-opioid receptor. [PDF]
Agyemang E +13 more
europepmc +1 more source

