Results 191 to 200 of about 134,149 (308)

Investigating Opioid Receptor Activity through Biocatalytic Halogenation and Oxidation of Mitragynine. [PDF]

ACS Chem Biol
Harris NR, Powell AJ, Snodgrass HM, Amin S, Newmister SA, Curtis BJ, Li D, Husaini ZA, Verhey-Henke L, Smith JL, Pereira F, Lewis JC, Traynor J, Sherman DH.   +13 more
europepmc   +1 more source

A Transferable and Robust Computational Framework for Class A GPCR Activation Free Energies. [PDF]

J Phys Chem Lett
Aureli S, Piasentin N, Fröhlking T, Rizzi V, Gervasio FL.   +4 more
europepmc   +1 more source

Identification of Crucial Drug Targets and Pathways to Reprogram Drug Resistance Through Epigenetic Modulation in Advanced Lung Cancer Using Integrated Bioinformatics Approach

Computational and Systems Oncology, Volume 6, Issue 1, December 2026.
ABSTRACT Resistance to chemotherapy, which is demonstrated in almost every patient with advanced‐stage lung cancer (ALC), underscores an urgent need to unravel the underlying molecular mechanisms and identify novel strategies to overcome drug resistance. In the present study, an attempt was made to identify epigenetic targets and modulators that can be
Okibur Rahman, Mossammat Rima Akter, Nur Alam   +2 more
wiley   +1 more source

Factors Associated With Poor One-Month Glasgow Outcome Scale Scores After Traumatic Brain Injury With Intracranial Hemorrhage in Adult Patients Presenting to the Emergency Department. [PDF]

Emerg Med Int
Tienpratarn W, Phinyo P, Yuksen C, Wongwaisayawan S, Khorana J, Patumanond J, Seesuklom S.   +6 more
europepmc   +1 more source

On the additive image of zeroth persistent homology

Transactions of the London Mathematical Society, Volume 13, Issue 1, December 2026.
Abstract For a category X$X$ and a finite field F$F$, we study the additive image of the functor H0(−;F)∗:rep(X,Top)→rep(X,VectF)$\operatorname{H}_0(-;F)_* \colon \operatorname{rep}(X, \mathbf {Top}) \rightarrow \operatorname{rep}(X, \mathbf {Vect}_F)$, or equivalently, of the free functor rep(X,Set)→rep(X,VectF)$\operatorname{rep}(X, \mathbf {Set ...
Ulrich Bauer, Magnus B. Botnan, Steffen Oppermann, Johan Steen   +3 more
wiley   +1 more source

Computational Pharmacodynamic Analysis of Cyclopeptides Derived from c[Trp-Phe-D-Pro-Phe] (CJ-15,208), an Unusual Class of Mixed μ/k-Opioid Receptor Ligands Lacking the Traditional Pharmacophores. [PDF]

Biomedicines
Francescato M, Liao H, Cavina L, Bedini A, Gentilucci L.   +4 more
europepmc   +1 more source

Production routing decisions in a two‐echelon supply chain with multiple delivery modes

International Transactions in Operational Research, Volume 33, Issue 5, Page 3385-3421, September 2026.
Abstract We study an original two‐echelon production routing problem with multiple delivery modes (2E‐PRP‐MDM). In the first echelon, the primary production facility is tasked with satisfying the demands of two distinct entities: a set of warehouses and a set of customers through direct shipments. In the second echelon, warehouses become delivery hubs,
Rachida Benfedel, Fayçal Belkaid, Nadjib Brahimi   +2 more
wiley   +1 more source

Structural and Pharmacological Characterization of AT-121 Reveals Carbonic Anhydrase Inhibition as a Complementary Mechanism to Dual MOR/NOR Agonism. [PDF]

ACS Med Chem Lett
Bonardi A, Ferraroni M, Gratteri P, Supuran CT, Angeli A.   +4 more
europepmc   +1 more source