Results 51 to 60 of about 1,410,399 (279)
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner +14 more
wiley +1 more source
Common Morality and Moral Reform
, 2009 The idea of moral reform requires that morality be more than a description of what people do value, for there has to be some measure against which to assess progress. Otherwise, any change is not reform, but simply difference.
Wallace, K.A.
core +1 more source
, 2010 Over the last few decades, scientists have been busy debunking the myth that nonhuman animals relate to each other in a primarily competitive, aggressive way.
Sachs, Benjamin Alan +1 more
core +1 more source
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Justifying group-specific common morality
, 2008 Some defenders of the view that there is a common morality have conceived such morality as being universal, in the sense of extending across all cultures and times.
Carson Strong, Strong, Carson
core +1 more source
ETHICAL AND PSYCHOLOGICAL REQUIREMENTS FOR A FORENSIC EXPERT IN THE CRIMINAL PROCESS
Хабаршы. Заң сериясы, 2020 Until recently, due attention has not been paid to issues of professional ethics and morality of justice workers as an important element of the culture of criminal proceedings.
Sh.B. Malikova, A.K. Igilikova
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Morality, Imagination and Human decision making
Verbum et Ecclesia, 2001 The authors of this article explore the possibility of using imagination instead of so-called objective truths in human decision making. They argue that imagination plays a role even if one operates with the objectivist view of morality.
L.H. Human, J. Liebenberg, J.C. M�ller
doaj +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source