Results 71 to 80 of about 6,317 (257)

The Spiritual Task of Religion in Culture: An Evolutionary Perspective

open access: yesZygon, 1998
It is quite impossible to consider human nature within an evolutionary perspective if we leapfrog over culture and establish some direct relation between cosmic and human evolution without taking culture into consideration.
doaj   +2 more sources

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Peran Balaghah Terhadap Penafsiran Ayat-Ayat Akhlak Dalam Al-Qur’an

open access: yesJurnal El-Thawalib
Balaghah plays a vital role in understanding the beauty of the Qur’anic language, particularly in interpreting verses related to morality. Moral verses in the Qur’an are often conveyed through profound linguistic expressions, including word choice ...
Anwar Sidik, Rizka Sari
doaj   +1 more source

Some verbal patterns in the Castle of Perseverance

open access: yesKoers : Bulletin for Christian Scholarship, 1979
The pure fifteenth and sixteenth century ‘morality play’, of which The Castle of Perseverance is an instance, is far from being the dry ethical study this inaccurate term would suggest.
D. Levey
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

Carr as Thucydides’ ghostwriter: the paradox of realism and a moral foreign policy

open access: yesMeđunarodne Studije, 2017
The subject of this paper is to examine the role of morality in foreign policy decision making and action, while its goal is to argue that (1) morality plays an important role in the creation of foreign policy, and (2) that it is not possible to ...
Stipe Buzar
doaj  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

A.L. Sakketti’s Historism and the Problem of the People

open access: yesRUDN Journal of Philosophy
The philosophy of Alexandr L. Sakketti (Saссhetti, 1881-1966) is still an understudied area. Researchers pay attention to his publication devoted to understanding the philosophy of law from the perspective of Marburg neo-Kantianism and to his translation
Mikhail Yu. Zagirnyak   +1 more
doaj   +1 more source

Liquid biopsy‐based diagnostic evaluation of hypermethylated CpG sites for ovarian cancer diagnosis

open access: yesMolecular Oncology, EarlyView.
This schematic outlines the workflow from biomarker identification to duplex MethyLight assay validation for epithelial ovarian cancer diagnosis using cfDNA‐based liquid biopsy. Initial screening of hypermethylated CpG candidates (cg02957270, cg10061138 cg00480298, COL2A1) was performed in tissue using ARMS‐PCR, COBRA, qPCR and image analysis. Selected
Deepa Bisht   +3 more
wiley   +1 more source

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