Results 111 to 120 of about 6,612,409 (279)
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
Learning with owls: Human–wildlife coexistence as a guide for urban design
People and NatureUrban encroachment increasingly threatens wildlife survival and well‐being, underscoring the need for design and management to consider nonhuman species. This article analyses cases of positive coexistence between humans and Powerful Owls (Ninox strenua)
Dan Parker +2 more
doaj +1 more source
Interaction Design and Architecture(s)This paper presents an exploratory study on approaches to the designer’s self-narration from a more-than-human-centered perspective. It aims to offer new perspectives on professional identity construction and sustainable design practices within ...
Eugenia Rosina, Francesca Mattioli
doaj +1 more source
β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1
Molecular Oncology, EarlyView.Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero +8 more
wiley +1 more source
A^2-Net: Molecular Structure Estimation from Cryo-EM Density Volumes
, 2019 Constructing of molecular structural models from Cryo-Electron Microscopy (Cryo-EM) density volumes is the critical last step of structure determination by Cryo-EM technologies.
Li, Hongsheng +4 more
core +1 more source
Designing-with More-than-Human Through Human Augmentation
The recent more-than-human turn in design calls for "designing-with" other species and ecologies beyond humans. Yet-as Thomas Nagel's famous "What is it like to be a bat?" thought experiment highlights-human experience is constrained by our own sensorium and an irreducible gap in phenomenal access to nonhuman lifeworlds.
Hu, Botao 'Amber', Huang, Danlin
openaire +2 more sources
Molecular Oncology, EarlyView.AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou +5 more
wiley +1 more source
Open PhilosophyIn response to this issue’s theme of Can robots be sensual? two propositions are discussed from a design researcher’s perspective. Four devices across two speculative projects Habitat Robots and Soil Protector Robots are presented.
Santer Steven C.
doaj +1 more source
Holographic Reduced Representations for Oscillator Recall: A Model of Phonological Production [PDF]
, 2002 This paper describes a new computational model of phonological production, Holographic Reduced Representations for Oscillator Recall, or HORROR. HORROR's architecture accounts for phonological speech error patterns by combining the hierarchical ...
Harris, Harlan
core +1 more source
Molecular Oncology, EarlyView.PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham +21 more
wiley +1 more source