Results 51 to 60 of about 1,008 (155)

Synthesis and Biological Evaluation of 14-Alkoxymorphinans. 22. Influence of the 14-Alkoxy Group and the Substitution in Position 5 in 14-Alkoxymorphinian-6-ones on in Vitro and in Vivo Activities

, 2005
Novel 14-alkoxy-substituted (e.g. allyloxy, benzyloxy, naphthylmethoxy) morphinan-6-one derivatives were synthesized and biologically evaluated. Compounds 6-9 and 11 displayed affinities in the subnanomolar range mu opioid receptors which were comparable
NEGRI, Lucia, SCHMIDHAMMER H., SPETEA M., LATTANZI, Roberta, RIEF S. B., SCHULLNER F., KRASSING R.   +6 more
core   +1 more source

N-Inversion-Associated Conformational Dynamics Is Unusually Rapid in Morphine Alkaloids

, 2016
13C DNMR studies of codeine and sinomenine (derivatives of N-Me morphinan) indicated that N-inversion−C−N rotation (NIR) is unusually fast for these substituted piperidines when compared with other N-Me piperidines.
Anatoly M. Belostotskii (2739955), Hugo E. Gottlieb (1537900), Zafrir Goren (2739952)   +2 more
core   +1 more source

Synthesis and Biological Evaluation of 14-Alkoxymorphinans. 22. Influence of the 14-Alkoxy Group and the Substitution in Position 5 in 14-Alkoxymorphinan-6-ones on in Vitro and in Vivo Activities

, 2016
Novel 14-alkoxy-substituted (e.g. allyloxy, benzyloxy, naphthylmethoxy) morphinan-6-one derivatives were synthesized and biologically evaluated. Compounds 6−9 and 11 displayed affinities in the subnanomolar range to μ opioid receptors which were ...
Falko Schüllner (2683948), Helmut Schmidhammer (576205), Mariana Spetea (576206), Lucia Negri (843184), Roland Krassnig (2683954), Roberta Lattanzi (843185), Silvia B. Rief (2683951)   +6 more
core   +1 more source

Studies on Cycloadducts of Thebaine and Thioaldehydes [PDF]

, 1993
A new route to the synthesis of 14beta-alkylmorphinans, of interest as potential analgesics, has been developed. Several such morphinans have been produced by desulphurisation of the Diels-Alder cycloadducts of thebaine and thioaldehydes, or of related ...
McQuillan, James Thomas
core   +1 more source

Salutaridine and its derivatives as thebaine-equivalents in the synthesis of aporphines

Open Chemistry, 2013
Udvardy Antal, Sipos Attila
doaj   +1 more source

Structure-Kinetics Relationships of Opioids from Metadynamics and Machine Learning Analysis. [PDF]

J Chem Inf Model, 2023
Mahinthichaichan P, Liu R, Vo QN, Ellis CR, Stavitskaya L, Shen J.   +5 more
europepmc   +1 more source

Biosynthesis of benzylisoquinoline alkaloids and its evolution in plants. [PDF]

Plant Commun
Tian Y, An Z, Li Q, Bai G, Zhang Q, Dong Y, Chen Y, Chen S, Xu Z, Gao R.   +9 more
europepmc   +1 more source

Efficacy and safety of anrikefon in the treatment of diabetic hemodialysis patients with pruritus: a post hoc analysis. [PDF]

BMC Nephrol
Li ZL, Li ZY, Pan MM, Liu BC.
europepmc   +1 more source

The Metabolome of the <i>Ocotea</i> spp.: From Biosynthetic Aspects to Bioactive Chemical Scaffolds by Integrating the Genus Chemical Database (<i>Ocotea</i>DB). [PDF]

J Nat Prod
Katchborian-Neto A, de Jesus Nicácio K, Bueno PCP, Ferreira MS, Fernandes Alves M, de Oliveira Silva D, Dos Santos WT, de Monroe Gonçalves M, de Paula ACC, Dias DF, Soares MG, Edrada-Ebel R, Lago JHG, Chagas-Paula DA.   +13 more
europepmc   +1 more source

Concise synthesis of (R)-reticuline and (+)-salutaridine by combining early-stage organic synthesis and late-stage biocatalysis. [PDF]

Chem Sci, 2023
Cigan E, Pletz J, Berger SA, Hierzberger B, Grilec-Zlamal M, Steiner A, Oroz-Guinea I, Kroutil W.   +7 more
europepmc   +1 more source