Results 31 to 40 of about 1,008 (155)
Food Science &Nutrition, Volume 14, Issue 5, May 2026.Moroccan medicinal plants with in silico‐approved aphrodisiac effects provide 94 phytochemicals. Docking against PDE5, AR, ERα, and aromatase gives top scores for lutein (−10.6), baicalein (−9.5), liquiritigenin (−9.2), and procyanidins (−9.7). ADMET filtering passes baicalein and liquiritigenin but excludes lutein and procyanidins. MD simulations (200
Amal Elrherabi +8 more
wiley +1 more source
Papaver somniferum and P. bracteatum: Tissue culture and morphinan alkaloid production.
, 1987 Papaver somniferum plants accumulate the secondary products codeine and morphine. P. bracteatum accumulates their precursor, thebaine. The aims of the project were to use tissue cultures for the production of these alkaloids and for the biotransformation
Keith B. Day (7700954)
core +4 more sources
Health Science Reports, Volume 9, Issue 5, May 2026.ABSTRACT Background and Aims Obsessive–compulsive disorder (OCD) is a chronic condition associated with marked functional impairment and high rates of treatment resistance. Converging evidence implicates glutamatergic dysregulation in OCD pathophysiology.
Ahmad Zolghadriha +2 more
wiley +1 more source
, 1960 The preparation of levorphanol, dextrorphan and morphine stereoselective adsorbents is described. These adsorbents are used to show that the laevo isomers of morphine, phenazocine and a related compound, and racemorphan and related morphinans have ...
Patricia Anderson, A H Beckett
core +1 more source
, 2020 Morphine and structurally-derived compounds are mu opioid receptor (mu OR) agonists, and the most effective analgesic drugs. However, their usefulness is limited by serious side effects, including dependence and abuse potential.
Dumitrascuta, Maria +9 more
core +1 more source
A structure-affinity study of the opioid binding of some 3-substituted morphinans [PDF]
, 2004 A ZINDO/1 quantum-chemical structure-affinity relationship study is presented for the interaction of a group of 3-substituted morphinans with mu, delta and kappa opioid receptors. From this and previous work it is concluded that: 1.
Hurtado, S. Marcela +2 more
core
Clinical Case Reports, Volume 14, Issue 1, January 2026.ABSTRACT Sinomenine, derived from Sinomenium acutum, is widely used in inflammatory diseases. However, its risk of inducing agranulocytosis is not widely appreciated. We report a life‐threatening case in a 40‐year‐old woman with chronic kidney disease (CKD; baseline estimated glomerular filtration rate [eGFR] as low as 36 mL/min/1.73 m2) who developed ...
Ping Xin, Ruoyan Liu, Yu Zhang, Bin Fu
wiley +1 more source
International Journal of Genomics, Volume 2026, Issue 1, 2026.Medicinal and aromatic plants (MAPs) produce a remarkable diversity of specialized metabolites with significant pharmaceutical, nutraceutical, and industrial value. Although advances in long‐read sequencing, chromosome‐scale genome assembly, and pangenomics have greatly expanded genomic resources, the mechanistic links between genome architecture and ...
Himanshu Saini +11 more
wiley +1 more source
Drug Testing and Analysis, Volume 17, Issue 10, Page 1996-2004, October 2025.Close collaboration between an Australian drug checking service and an affiliated university laboratory identifies and characterises the novel synthetic opioid N‐pyrrolidino isotonitazene in an expected oxycodone sample presented by a member of the public.
Blake Curtis +3 more
wiley +1 more source
British Journal of Pharmacology, Volume 182, Issue 14, Page 3163-3177, July 2025.Graph‐based algorithms that enable efficient computations of all H‐bonds present in structures in entire datasets allow us to dissect H‐bond fingerprints that characterize distinct GPCRs and the structures sampled along their activation. Abstract Changes in structure and dynamics elicited by agonist ligand binding at the extracellular side of G protein
Éva Bertalan +3 more
wiley +1 more source