Results 41 to 50 of about 1,008 (155)
, 2016 The phenolic group of the potent μ and κ opioid morphinan agonist/antagonists cyclorphan and butorphan was replaced by phenylamino and benzylamino groups including compounds with para-substituents in the benzene ring.
Jean M. Bidlack (1313052) +4 more
core +1 more source
ChemPlusChem, Volume 90, Issue 6, June 2025.Accelerated drug derivatization in microdroplets combined with high‐throughput desorption electrospray ionization mass spectrometry provides rapid reaction screening and label‐free bioassay results, which can expedite drug discovery. Adapting high‐throughput (HT) synthetic methods to the modification of drugs and to testing of their bioactivity should ...
Jyotirmoy Ghosh +3 more
wiley +1 more source
Characterization of Opioid Agonist Morphine Derivatives with Emphasis on Medicinal Chemistry
ChemMedChem, Volume 20, Issue 4, February 16, 2025.The aim of synthesizing new opioid compounds is to produce drugs that are more potent, less addictive, and have fewer side effects, such as respiratory depression and constipation. To achieve this, we evaluated the basicity, lipophilicity, and permeability of 30 opioid compounds, including 11 newly synthesized ones, to better understand the ...
Alaa Malik +7 more
wiley +1 more source
, 2016 In a continued effort to find new substitution patterns in morphinans that would produce strong antinociception while inducing lesser side effects, 4,5-oxygen bridge-opened 6-cyano-substituted N-methylmorphinans (1−3) were synthesized.
Mario D. Aceto (2384371) +5 more
core +1 more source
Phenol (bio)isosteres in drug design and development
Archiv der Pharmazie, Volume 358, Issue 1, January 2025.This review explores the pivotal role of phenol bioisosteres in drug design, highlighting their potential to overcome the limitations of phenolic compounds, such as poor bioavailability and rapid metabolism. By examining diverse bioisosteric replacements, from benzimidazolones to quinolinones, it is demonstrated how these modifications enhance drug ...
Calvin Dunker +2 more
wiley +1 more source
The Application of Metallated Enamines to the Synthesis of Morphine Alkaloids [PDF]
, 1982 Metallated enamines have been used to prepare a number of morphine-based analgesics, including efficient entry to the 4a-phenylisoquinolines and morphinans.
Mitch, Charles Howard
core +1 more source
, 1966 1. Diphenylpropylamines / by P. A. J. Janssen2A. Morphinans / by J. Hellerbach, O. Schnider, H. Besendorf e. a.2B. 6.7-Benzomorphans / by N. B. Eddy and E. L. May.Pt.
Janssen, Paul Adriaan Jan,Baron,1926-2003(viaf)32253568 +5 more
core
Morphinan alkaloids from the leaves of Alphonsea cylindrica and their antibacterial properties
, 2023 A phytochemical study has been carried out on CH (2) Cl (2) extract of Alphonsea cylindrica leaves, resulting in the isolation of three new morphinan alkaloids. They are kinomenine ( 1 ), N -methylkinomenine ( 2 ), and hydroxymethylkinomenine ( 3 ).
Tan, Siow-Ping +4 more
core +1 more source
Isoquinoline Alkaloids from the Leaves of Dehaasia Hainanensis
, 2008 This study was aimed at investigating the alkaloids present in the leaves of Dehaasia hainanensis. Thirteen isoquinolines were isolated and characterized. Of these, four aporphines [(+)-laurolitsine, (+)-corydine, (+)- laurotetanine and (+)-lindcarpine],
CHEN, CHIEN-KUANG;CHEN, CHUNG-HSIUNG;LEE, SHOEI-SHENG +1 more
core
Formal Synthesis of (+/-) Morphine via an Oxy-cope/Claisen/Ene Reaction Cascade
, 2012 For years now, opium alkaloids and morphinans have been attractive synthetic targets for numerous organic chemists due to their important biological activity and interesting molecular architecture.
Marcotte, Joel
core +1 more source