Results 21 to 30 of about 881 (169)
The opium poppy genome and morphinan production [PDF]
Science, 2018 Poppy genome reveals evolution of opiates The opium poppy has been a source of painkillers since Neolithic times. Attendant risks of addiction threaten many today. Guo et al. now deliver a draft of the opium poppy genome, which encompasses 2.72 gigabases assembled into 11 chromosomes and predicts more than
Li Guo +10 more
openaire +3 more sources
, 2016 Novel Class of Morphinans with Acrylonitrile Incorporated Substructures as Key Intermediates for Non-Oxygen-Bridged Opioid ...
Elisabeth Greiner (2089093) +3 more
core +2 more sources
N-Phenethyl Substitution in 14-Methoxy-N-methylmorphinan-6-ones Turns Selective µ Opioid Receptor Ligands into Dual µ/δ Opioid Receptor Agonists. [PDF]
, 2020 Morphine and structurally-derived compounds are µ opioid receptor (µOR) agonists, and the most effective analgesic drugs. However, their usefulness is limited by serious side effects, including dependence and abuse potential.
Lantero, A. (Aquilino) +25 more
core +1 more source
Angewandte Chemie, Volume 138, Issue 16, 13 April 2026.Photocatalytic cross‐coupling: A redox‐neutral photochemical method enables direct C(sp2)─C(sp2) bond formation between phenols and heteroaryl halides using an organic dye and base. Complementary radical generation allows efficient cross‐coupling in up to 91% yield. Mechanistic studies, DFT, HTE, and machine learning rationalize and predict reactivity,
Matthew C. Carson +4 more
wiley +2 more sources
, 2016 To further extend the structure−activity relationships of levorphanol, two series of novel morphinans were prepared by incorporation of an indole or aminothiazole fragment to the hexyl ring (ring C) in levorphanol.
Jean M. Bidlack (1313052) +6 more
core +1 more source
, 2020 The growing demand for opioid antagonists necessitates the development of more efficient and affordable synthetic routes. The most challenging step in the preparation of these essential medicines is the selective N-demethylation of a 14-hydroxy opioid ...
Gabriel, Glotz +2 more
core +1 more source
2-Aminothiazole-Derived Opioids. Bioisosteric Replacement of Phenols
, 2016 A series of aminothiazole-derived morphinans, benzomorphans, and morphine were synthesized. Although their affinities were somewhat lower than their phenol prototypes, one compound (9a, ATPM) has been identified possessing high affinity and selectivity ...
Jean M. Bidlack (1313052) +5 more
core +3 more sources
Photochemical Decatungstate‐Catalyzed Hydroacylation of Maleimides
European Journal of Organic Chemistry, Volume 29, Issue 20, 27 May 2026.A photocatalytic protocol to access substituted succinimides via tetra‐n‐butylammonium decatungstate photocatalysis is reported. This direct radical‐driven hydroacylation of a variety of N‐substituted maleimides shows tolerance to various aldehydes (or alkanes), affording differentially substituted succinimides in high yields. Succinimides constitute a
Manos V. G. Lantzanakis +2 more
wiley +1 more source
, 2023 Hallucinogens are a large class of psychoactive compounds known for their unique perception-altering effects. Hallucinogenic fungi, plant and animal alkaloids have been used by indigenous peoples for thousands of years, and today these alkaloids, their ...
Fu, S, Alonzo, M
core +1 more source
Dearomatization with Axial‐to‐Central Chirality Conversion
European Journal of Organic Chemistry, Volume 29, Issue 17, 5 May 2026.Atropisomers are exciting synthetic targets with unique properties, which find applications in many fields of chemistry. However, considering them as substrates is not very frequent, notably in the context of dearomatization reaction. We wish to discuss the different strategies for the dearomatization of aromatic atropisomers with axial‐to‐central ...
Morgane Mando +3 more
wiley +1 more source