Results 21 to 30 of about 775 (130)

Life‐Threatening Agranulocytosis Induced by Sinomenine Hydrochloride in Chronic Kidney Disease: A Case Report and Literature Review

Clinical Case Reports, Volume 14, Issue 1, January 2026.
ABSTRACT Sinomenine, derived from Sinomenium acutum, is widely used in inflammatory diseases. However, its risk of inducing agranulocytosis is not widely appreciated. We report a life‐threatening case in a 40‐year‐old woman with chronic kidney disease (CKD; baseline estimated glomerular filtration rate [eGFR] as low as 36 mL/min/1.73 m2) who developed ...
Ping Xin, Ruoyan Liu, Yu Zhang, Bin Fu
wiley   +1 more source

Identification of the Novel Synthetic Opioid N‐Pyrrolidino Isotonitazene at an Australian Drug Checking Service

Drug Testing and Analysis, Volume 17, Issue 10, Page 1996-2004, October 2025.
Close collaboration between an Australian drug checking service and an affiliated university laboratory identifies and characterises the novel synthetic opioid N‐pyrrolidino isotonitazene in an expected oxycodone sample presented by a member of the public.
Blake Curtis, Douglas J. Lawes, David Caldicott, Malcolm D. McLeod   +3 more
wiley   +1 more source

Graph‐based algorithms to dissect long‐distance water‐mediated H‐bond networks for conformational couplings in GPCRs

British Journal of Pharmacology, Volume 182, Issue 14, Page 3163-3177, July 2025.
Graph‐based algorithms that enable efficient computations of all H‐bonds present in structures in entire datasets allow us to dissect H‐bond fingerprints that characterize distinct GPCRs and the structures sampled along their activation. Abstract Changes in structure and dynamics elicited by agonist ligand binding at the extracellular side of G protein
Éva Bertalan, Matthew Joseph Rodrigues, Gebhard F. X. Schertler, Ana‐Nicoleta Bondar   +3 more
wiley   +1 more source

High‐Throughput Drug Derivatization and Bioassay by Desorption Electrospray Ionization Mass Spectrometry

ChemPlusChem, Volume 90, Issue 6, June 2025.
Accelerated drug derivatization in microdroplets combined with high‐throughput desorption electrospray ionization mass spectrometry provides rapid reaction screening and label‐free bioassay results, which can expedite drug discovery. Adapting high‐throughput (HT) synthetic methods to the modification of drugs and to testing of their bioactivity should ...
Jyotirmoy Ghosh, Nicolás M. Morato, Yunfei Feng, R. Graham Cooks   +3 more
wiley   +1 more source

Characterization of Opioid Agonist Morphine Derivatives with Emphasis on Medicinal Chemistry

ChemMedChem, Volume 20, Issue 4, February 16, 2025.
The aim of synthesizing new opioid compounds is to produce drugs that are more potent, less addictive, and have fewer side effects, such as respiratory depression and constipation. To achieve this, we evaluated the basicity, lipophilicity, and permeability of 30 opioid compounds, including 11 newly synthesized ones, to better understand the ...
Alaa Malik, Sándor Hosztafi, Anna Vincze, András Marton, Márta Kraszni, György T. Balogh, Béla Noszál, Károly Mazák   +7 more
wiley   +1 more source

Phenol (bio)isosteres in drug design and development

Archiv der Pharmazie, Volume 358, Issue 1, January 2025.
This review explores the pivotal role of phenol bioisosteres in drug design, highlighting their potential to overcome the limitations of phenolic compounds, such as poor bioavailability and rapid metabolism. By examining diverse bioisosteric replacements, from benzimidazolones to quinolinones, it is demonstrated how these modifications enhance drug ...
Calvin Dunker, Katja Schlegel, Anna Junker   +2 more
wiley   +1 more source

Modification of Gene Expression Involved in Alkaloid Production in Opium Poppy by VIGS Combined With Pretreatment of Macerozyme Enzyme

Plant Direct, Volume 9, Issue 1, January 2025.
ABSTRACT Papaver somniferum L., a medicinal plant renowned for its pharmaceutical alkaloids, has captivated scientific interest due to its rich secondary metabolite profile. This study explores a novel approach to manipulating alkaloid biosynthesis pathways by integrating virus‐induced gene silencing (VIGS) with macerozyme enzyme pretreatment ...
Deniz Ece Özcan, Deniz Köm, Ozan Doğan, Semiha Erişen, Selma Onarici   +4 more
wiley   +1 more source

Development of the Japanese Anticholinergic Risk Scale: English translation of the Japanese article

Geriatrics &Gerontology International, Volume 25, Issue 1, Page 5-13, January 2025.
Background Anticholinergic burden, reflecting the cumulative impact of medications with anticholinergic properties, significantly predicts adverse drug reactions and geriatric syndromes in older adults. Although anticholinergic risk scales (ARS) have been developed and validated in various countries, none have been tailored specifically for Japan.
Fumihiro Mizokami, Tomohiro Mizuno, Rena Taguchi, Izumi Nasu, Sayaka Arai, Keiichiro Higashi, Ayaka Matsumoto, Miwako Kamei, Taro Kojima, Takayoshi Sakai, Yuuka Shibata, Yasushi Takeya, Masaki Mogi, Shizuo Yamada, Masahiro Akishita, Japanese Society of Geriatric Pharmacy Working Group on Japanese Anticholinergic Risk Scale   +15 more
wiley   +1 more source

Phytochemical Profile and Assessment of In Vivo Anti‐Inflammatory Efficacy of Ficus sycomorus L. (Moraceae) Extracts in Mice

Scientifica, Volume 2025, Issue 1, 2025.
Inflammation helps the immune system identify and eliminate disease‐causing and foreign stimuli and initiate the healing process. Nonsteroidal anti‐inflammatory drugs have been often used in treating inflammation. Synthetic drugs have been associated with severe effects, necessitating the need for alternative medicinal agents.
Stephen Maina Gitahi, Eunice Wothaya Muthee, Mathew Piero Ngugi, Alex Kingori Machocho, Simone Carradori   +4 more
wiley   +1 more source

Structure-Kinetics Relationships of Opioids from Metadynamics and Machine Learning Analysis. [PDF]

J Chem Inf Model, 2023
Mahinthichaichan P, Liu R, Vo QN, Ellis CR, Stavitskaya L, Shen J.   +5 more
europepmc   +1 more source