Results 11 to 20 of about 1,008 (155)
A functionally conserved STORR gene fusion in Papaver species that diverged 16.8 million years ago. [PDF]
Nat Commun, 2022 The STORR gene fusion event is considered essential for the evolution of the promorphinan/morphinan subclass of benzylisoquinoline alkaloids (BIAs) in opium poppy as the resulting bi-modular protein performs the isomerization of (S)- to (R)-reticuline ...
Catania T +11 more
europepmc +2 more sources
The Vinylogous Aldol Reaction of Furoate Esters and the Synthesis of Unnatural Enantiomer Morphinans as TLR4 Inhibitors [PDF]
, 2015 While in the Sammakia Lab, I have focused on developing and applying new approaches to organic synthesis and the creation of novel cell-signaling inhibitors.
Hartwig, William T.
core +6 more sources
A Modular Chemoenzymatic Cascade Simplifies Divergent Synthesis of Natural and Unnatural Benzylisoquinoline Alkaloids. [PDF]
Adv Sci (Weinh)A simplified chemoenzymatic platform is designed to integrate an enzyme cascade with subsequent chemical steps, enabling the divergent production of diverse benzylisoquinoline alkaloids (BIAs). Demonstrating remarkable versatility and enantioselectivity, four distinct classes of BIAs are efficiently generated, in which the natural medicine papaverine ...
Liu H +8 more
europepmc +2 more sources
Archaeometry, EarlyView., 2022 Abstract Organic residue analysis was conducted on various vessels from burials at Tel Yehud, Israel. The analyses led to new reliable evidence for the presence of opioid alkaloids and their decomposition products. This research revitalizes a decades‐old discussion on the presence and function of the opium trade across a cultural region of utmost ...
Vanessa Linares +5 more
wiley +1 more source
, 2016 Novel Class of Morphinans with Acrylonitrile Incorporated Substructures as Key Intermediates for Non-Oxygen-Bridged Opioid ...
Elisabeth Greiner (2089093) +3 more
core +2 more sources
Chemistry and biology of ent-morphinan alkaloids
, 2023 International audienceMorphinan alkaloids have attracted constant attention since the isolation of morphine by Sertürner in 1805. However, a group of 45 compounds possessing a complete ent-morphinan backbone can also be found in the literature.
Porée, François-Hugues +2 more
core +1 more source
, 2016 To further extend the structure−activity relationships of levorphanol, two series of novel morphinans were prepared by incorporation of an indole or aminothiazole fragment to the hexyl ring (ring C) in levorphanol.
Jean M. Bidlack (1313052) +6 more
core +2 more sources
, 2020 International audienceAchieving in a straightforward way the synthesis of enantioenriched elaborated three-dimensional molecules related to bioactive natural products remains a long-standing quest in organic synthesis.
Agnès Martin‐Mingot +13 more
core +5 more sources
2-Aminothiazole-Derived Opioids. Bioisosteric Replacement of Phenols
, 2016 A series of aminothiazole-derived morphinans, benzomorphans, and morphine were synthesized. Although their affinities were somewhat lower than their phenol prototypes, one compound (9a, ATPM) has been identified possessing high affinity and selectivity ...
Jean M. Bidlack (1313052) +5 more
core +3 more sources
N-Phenethyl Substitution in 14-Methoxy-N-methylmorphinan-6-ones Turns Selective µ Opioid Receptor Ligands into Dual µ/δ Opioid Receptor Agonists. [PDF]
, 2020 Morphine and structurally-derived compounds are µ opioid receptor (µOR) agonists, and the most effective analgesic drugs. However, their usefulness is limited by serious side effects, including dependence and abuse potential.
Lantero, A. (Aquilino) +25 more
core +1 more source