Results 11 to 20 of about 881 (169)
Chemistry and biology of ent-morphinan alkaloids
, 2023 Morphinan alkaloids have attracted constant attention since the isolation of morphine by Sertürner in 1805. However, a group of 45 compounds possessing a complete ent-morphinan backbone can also be found in the literature. These compounds are related to the morphinandienone subgroup and display a substitution pattern which is different from the ...
Keita, Antoinette +2 more
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Electrospray tandem mass spectrometric investigations of morphinans [PDF]
Journal of the American Society for Mass Spectrometry, 2003 In this study positive ESI tandem mass spectra of the [M + H]+ ions of morphinan alkaloids obtained using an ion trap MS were compared with those from a triple quadrupole MS. This allows to assess the differences of the tandem-in-time versus the tandem-in-space principle, often hampering the development of ESI MS/MS libraries.
Raith, Klaus +5 more
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Synthetic investigations on Morphinans
, 1980 Applied ...
Olieman, C. (author), Olieman, C.
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A Modular Chemoenzymatic Cascade Simplifies Divergent Synthesis of Natural and Unnatural Benzylisoquinoline Alkaloids. [PDF]
Adv Sci (Weinh)A simplified chemoenzymatic platform is designed to integrate an enzyme cascade with subsequent chemical steps, enabling the divergent production of diverse benzylisoquinoline alkaloids (BIAs). Demonstrating remarkable versatility and enantioselectivity, four distinct classes of BIAs are efficiently generated, in which the natural medicine papaverine ...
Liu H +8 more
europepmc +2 more sources
A functionally conserved STORR gene fusion in Papaver species that diverged 16.8 million years ago. [PDF]
Nat Commun, 2022 The STORR gene fusion event is considered essential for the evolution of the promorphinan/morphinan subclass of benzylisoquinoline alkaloids (BIAs) in opium poppy as the resulting bi-modular protein performs the isomerization of (S)- to (R)-reticuline ...
Catania T +11 more
europepmc +2 more sources
Archaeometry, EarlyView., 2022 Abstract Organic residue analysis was conducted on various vessels from burials at Tel Yehud, Israel. The analyses led to new reliable evidence for the presence of opioid alkaloids and their decomposition products. This research revitalizes a decades‐old discussion on the presence and function of the opium trade across a cultural region of utmost ...
Vanessa Linares +5 more
wiley +1 more source
Lethality of the morphinan isomers levorphanol and dextrorphan [PDF]
British Journal of Pharmacology, 1973 Significantly different ...
R, Dingledine, A, Goldstein
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