Results 211 to 220 of about 339,726 (399)

PKC-Mediated Potentiation of Morphine Analgesia by St. John’s Wort in Rodents and Humans

open access: yesJournal of Pharmacological Sciences, 2014
Our purpose was to combine the use of morphine with clinically available inhibitors of protein kinase C (PKC), finally potentiating morphine analgesia in humans.
Nicoletta Galeotti   +3 more
doaj  

Abuse of gabapentinoids in individuals with substance use disorders

open access: yesJournal of Forensic Sciences, EarlyView.
Abstract The abuse of gabapentinoids has increased rapidly, and death cases have been reported with increasing rates. This study examines the toxicological analysis data of substance abuse cases conducted after legal regulations were implemented in Türkiye.
İnci Sağlam   +3 more
wiley   +1 more source

Role of kappa‐opioid and mu‐opioid receptors in pruritus: Peripheral and central itch circuits

open access: yesExperimental Dermatology, Volume 31, Issue 12, Page 1900-1907, December 2022., 2022
Abstract Modern genetic approaches in animal models have unveiled novel itch‐specific neural pathways, emboldening a paradigm in which drugs can be developed to selectively and potently target itch in a variety of chronic pruritic conditions. In recent years, kappa‐opioid receptors (KORs) and mu‐opioid receptors (MORs) have been implicated in both the ...
Brian S. Kim   +5 more
wiley   +1 more source

EVALUATION OF THE EFFECTS OF ADDING ORAL PREGABALINE TO MORPHINE IN PATIENTS-CONTROLLED IV ANALGESIA (PCIA) AFTER ORTHOPEDIC SURGERY [PDF]

open access: yes
Background: Optimal pain treatment with minimal side-effects is essential to allow early mobility, optimal functional recovery, and to reduce postoperative morbidity and mortality.
اخوان اکبری, قدرت   +4 more
core  

Comparison of the analgesic dose of intravenous ketamine versus ketorolac in patients with chest trauma: A randomized double‐blind clinical trial

open access: yesAcademic Emergency Medicine, EarlyView.
Abstract Background Pain management is a critical part of treatment in patients with chest trauma. Opioids and nonsteroidal anti‐inflammatory drugs have been the most commonly used medications. However, their side effects have drawn attention to other medications.
Hossein Zabihi Mahmoodabadi   +4 more
wiley   +1 more source

Patients' experiences and perceptions of dignity in end‐of‐life care in emergency departments: A qualitative study

open access: yesJournal of Advanced Nursing, Volume 79, Issue 1, Page 269-280, January 2023., 2023
Abstract Aims To explore and understand the experiences of patients with advanced illness in relation to dignity during end‐of‐life care in emergency departments. Design Qualitative study based on Gadamer's hermeneutics. Methods Between September 2019 and February 2020, 16 in‐depth interviews were carried out with advanced illness patients who attended
Celia Martí‐García   +6 more
wiley   +1 more source

Gene Expression Profile of Calcium/Calmodulin-Dependent Protein Kinase IIα in the Rat Hippocampus during Morphine Withdrawal

open access: yesBasic and Clinical Neuroscience, 2013
Introduction: Calcium/calmodulin-dependent protein kinase II (CaMKII) is highly expressed in the hippocampus, which has a pivotal role in reward-related memories and morphine dependence.
Shamseddin Ahmadi   +3 more
doaj  

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