Results 261 to 270 of about 162,133 (313)
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Acta Anaesthesiologica Scandinavica, 1997
Morphine is a potent opioid analgesic widely used for the treatment of acute pain and for long‐term treatment of severe pain. Morphine is a member of the morphinan‐framed alkaloids, which are present in the poppy plant. The drug is soluble in water, but its solubility in lipids is poor.In man, morphine‐3‐glucuronide (M3G) and morphine‐6‐glucu‐ronide ...
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Morphine is a potent opioid analgesic widely used for the treatment of acute pain and for long‐term treatment of severe pain. Morphine is a member of the morphinan‐framed alkaloids, which are present in the poppy plant. The drug is soluble in water, but its solubility in lipids is poor.In man, morphine‐3‐glucuronide (M3G) and morphine‐6‐glucu‐ronide ...
exaly +3 more sources
Morphine Metabolism and Morphine Tolerance in Goldfish
Anesthesiology, 1970Tolerance to morphine was induced in goldfish shown to be unable to metabolize morphine. Ability to metabolize is, therefore not a prercquisite to development of tolerance.
G A, Jansen, N M, Greene
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Morphine-Induced Attenuation of Morphine Tolerance
Science, 1981Rats experienced both morphine and an environmental cue, but the cue always signaled a drug-free period. They were subsequently administered morphine in the presence of the cue, and the development of analgesic tolerance was assessed. The prior experience retarded such tolerance.
S, Siegel, R E, Hinson, M D, Krank
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Psychopharmacology, 1976
The morphine blocking and anticonvulsant effects of propranolol were investigated in mice. Three different convulsant procedures (electroshock, pentylenetetrazol and thebaine) were used. In addition, LD50's of morphine after different doses of propranolol were done.
G, Navarro, R, Richardson, A T, Zuban
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The morphine blocking and anticonvulsant effects of propranolol were investigated in mice. Three different convulsant procedures (electroshock, pentylenetetrazol and thebaine) were used. In addition, LD50's of morphine after different doses of propranolol were done.
G, Navarro, R, Richardson, A T, Zuban
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Journal of the American Chemical Society, 2002
The preparation of the diastereomerically pure beta-tetralone ketal 4 is reported. Intramolecular alkylidene C-H insertion followed by hydrolysis of 4 proceeded to give the enantiomerically pure cyclopentene 15. The key step in this synthesis was the bis-intramolecular cyclization of keto aldehyde 2 to give the tetracyclic intermediate 20. Enone 20 was
Douglass F, Taber +2 more
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The preparation of the diastereomerically pure beta-tetralone ketal 4 is reported. Intramolecular alkylidene C-H insertion followed by hydrolysis of 4 proceeded to give the enantiomerically pure cyclopentene 15. The key step in this synthesis was the bis-intramolecular cyclization of keto aldehyde 2 to give the tetracyclic intermediate 20. Enone 20 was
Douglass F, Taber +2 more
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CNS Drugs, 2010
Oral morphine/naltrexone extended release capsules comprise the selective mu-opioid receptor agonist morphine in a sustained-release formulation combined with a sequestered core of the mu-opioid receptor antagonist naltrexone for use in the management of moderate to severe pain.
Sean T, Duggan, Lesley J, Scott
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Oral morphine/naltrexone extended release capsules comprise the selective mu-opioid receptor agonist morphine in a sustained-release formulation combined with a sequestered core of the mu-opioid receptor antagonist naltrexone for use in the management of moderate to severe pain.
Sean T, Duggan, Lesley J, Scott
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Trends in Neurosciences, 2000
It is now well accepted that endogenous morphine is present in animals, both in invertebrates and vertebrates. It is a key signaling molecule that plays an important role in downregulating physiological responses, such as those in the immune system, including immune elements in the CNS.
STEFANO GB +10 more
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It is now well accepted that endogenous morphine is present in animals, both in invertebrates and vertebrates. It is a key signaling molecule that plays an important role in downregulating physiological responses, such as those in the immune system, including immune elements in the CNS.
STEFANO GB +10 more
openaire +4 more sources