Results 331 to 340 of about 397,909 (400)
Impact of intraoperative methadone on early extubation and opioid utilization in intravenous drug users undergoing cardiac surgery. [PDF]
BMC AnesthesiolHoff A +6 more
europepmc +1 more source
The Mechanisms Involved in Morphine Addiction: An Overview
International Journal of Molecular Sciences, 2019 Opioid use disorder is classified as a chronic recurrent disease of the central nervous system (CNS) which leads to personality disorders, co-morbidities and premature death.
Joanna Listos +2 more
exaly +2 more sources
Morphine induces changes in the gut microbiome and metabolome in a morphine dependence model
Scientific Reports, 2018 Opioid analgesics are frequently prescribed in the United States and worldwide. However, serious comorbidities, such as dependence, tolerance, immunosuppression and gastrointestinal disorders limit their long-term use.
Fuyuan Wang, Jingjing Meng, Li Zhang
exaly +2 more sources
Proceedings of the National Academy of Sciences of the United States of America, 2019 Significance The last decade has seen an exponential increase in opioid use in the United States, resulting in a subset of the population developing opioid tolerance. In this paper, we unequivocally demonstrate that the gut microbiota plays a significant
Li Zhang, Jingjing Meng, Yuguang J Ban
exaly +2 more sources
Targeted exosome-mediated delivery of opioid receptor Mu siRNA for the treatment of morphine relapse
Scientific Reports, 2015 Cell-derived exosomes have been demonstrated to be efficient carriers of small RNAs to neighbouring or distant cells, highlighting the preponderance of exosomes as carriers for gene therapy over other artificial delivery tools.
Yuchen Liu, Zhengya Liu, Xiaohong Jiang
exaly +2 more sources
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CNS Drugs, 2010
Oral morphine/naltrexone extended release capsules comprise the selective mu-opioid receptor agonist morphine in a sustained-release formulation combined with a sequestered core of the mu-opioid receptor antagonist naltrexone for use in the management of moderate to severe pain.
Sean T, Duggan, Lesley J, Scott
openaire +2 more sources
Oral morphine/naltrexone extended release capsules comprise the selective mu-opioid receptor agonist morphine in a sustained-release formulation combined with a sequestered core of the mu-opioid receptor antagonist naltrexone for use in the management of moderate to severe pain.
Sean T, Duggan, Lesley J, Scott
openaire +2 more sources
Trends in Neurosciences, 2000
It is now well accepted that endogenous morphine is present in animals, both in invertebrates and vertebrates. It is a key signaling molecule that plays an important role in downregulating physiological responses, such as those in the immune system, including immune elements in the CNS.
STEFANO GB +10 more
openaire +4 more sources
It is now well accepted that endogenous morphine is present in animals, both in invertebrates and vertebrates. It is a key signaling molecule that plays an important role in downregulating physiological responses, such as those in the immune system, including immune elements in the CNS.
STEFANO GB +10 more
openaire +4 more sources
Science, 1970
The development of a radioimmunoassay for morphine is described. The hapten morphine is made antigenic by coupling it to a protein at the phenolic group of the molecule. Extremely low concentrations of morphine (0.5 nanogram) can be measured by this assay procedure.
S, Spector, C W, Parker
openaire +2 more sources
The development of a radioimmunoassay for morphine is described. The hapten morphine is made antigenic by coupling it to a protein at the phenolic group of the molecule. Extremely low concentrations of morphine (0.5 nanogram) can be measured by this assay procedure.
S, Spector, C W, Parker
openaire +2 more sources