Results 151 to 160 of about 254,310 (345)

CRISPR Screening Reveals a Novel Role for FOXH1 in Regulating Pluripotency of Porcine Embryonic Stem Cells

open access: yesAdvanced Science, EarlyView.
This study performs dual CRISPR screens in pEPSCs. Fitness screening identifies essential genes for viability, while FACS‐based screening uncovers core pluripotency factors. It highlights FOXH1 as a key regulator that maintains the stem cell state through a dual‐action mechanism: preserving pluripotency by enhancing chromatin accessibility and ...
Peng Su   +13 more
wiley   +1 more source

Decreasing the Cost of Morphing in Adaptive Morphogenetic Robots

open access: yesAdvanced Intelligent Systems, EarlyView.
Shape‐morphing propulsive limbs enhance locomotion across land‐to‐water transitions, but prior designs rely on thermally responsive components, coupling performance to environmental temperature. This study introduces a pressure‐responsive mechanism that reduces morphing energy costs, enables rapid transitions, and minimizes failure modes.
Luis A. Ramirez   +3 more
wiley   +1 more source

Chromosome 3q22.2‐q26.2 Interstitial Deletion in a Patient With Wisconsin Syndrome, Blepharophimosis‐Ptosis‐Epicanthus Inversus Syndrome, Dandy‐Walker Malformation, Pierre Robin Sequence, and Recurrent Infections

open access: yesAmerican Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Wisconsin syndrome is a very rare genetic condition characterized by coarse facies, prominent nasal tip, bushy high arched/upsweeping eyebrows, and a full/everted lower lip. Deletion of chromosome 3q24q25 region is considered critical for its manifestation.
Pankaj Prasun   +2 more
wiley   +1 more source

Neuroaxonal Dystrophy With Osteopetrosis Associated With a Novel Biallelic Nonsense Homozygous Variant in BORCS5

open access: yesAmerican Journal of Medical Genetics Part A, EarlyView.
ABSTRACT Neuroaxonal dystrophy (NAD) with osteopetrosis syndrome (OMIM # 600329) was first reported in a consanguineous Moroccan Jewish family. However, to date, no genetic variant has been linked to this disease. We report on sibs, born to consanguineous Pakistani parents identified prenatally with cerebral ventriculomegaly and agenesis of the corpus ...
Yael Fisher   +6 more
wiley   +1 more source

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