Results 91 to 100 of about 6,133,036 (272)

The cell biology of aging

, 2015
One of the original hypotheses of organismal longevity posits that aging is the natural result of entropy on the cells, tissues, and organs of the animal—a slow, inexorable slide into nonfunctionality caused by stochastic degradation of its parts.
Murphy, Coleen T, DiLoreto, Race
core   +1 more source

Mesenchymal cell invasion requires cooperative regulation of persistent microtubule growth by SLAIN2 and CLASP1 [PDF]

, 2016
Microtubules regulate signaling, trafficking, and cell mechanics, but the respective contribution of these functions to cell morphogenesis and migration in 3D matrices is unclear.
Noordstra, Ivar, Katrukha, Eugene A., Derksen, Patrick W. B., Katrukha, Eugene A, van Amersfoort, Miranda, Ter Hoeve, Natalie D, Celbiologie, Bouchet, Benjamin P, Derksen, Patrick W B, Dogterom, Marileen, Ammon, York-Christoph, Bouchet, Benjamin P., Hodgson, Louis, Sub Cell Biology, Akhmanova, Anna, ter Hoeve, Natalie D.   +15 more
core   +2 more sources

3D‐Printing Aided Rapid Prototyping of Pretensioned Tensegrity Structures for Robotic Applications

Advanced Robotics Research, EarlyView.
Printing, injection molding, and assembly (PMA) is a method for rapid prototyping mesoscale, topologically complex, and tensioned tensegrity structures. In combination with PMA method, two mold design strategies: modular mold and compact channel layout, enable efficiency and scalability for tensegrity fabrication.
Yi Sun, Jan Petrš, Omar Aloui, Dario Floreano   +3 more
wiley   +1 more source

PDX1+ cell budding morphogenesis in a stem cell-derived islet spheroid system

Nature Communications
Remarkable advances in protocol development have been achieved to manufacture insulin-secreting islets from human pluripotent stem cells (hPSCs). Distinct from current approaches, we devised a tunable strategy to generate islet spheroids enriched for ...
Jia Zhao, Shenghui Liang, Haoning Howard Cen, Yanjun Li, Robert K. Baker, Balwinder Ruprai, Guang Gao, Chloe Zhang, Huixia Ren, Chao Tang, Liangyi Chen, Yanmei Liu, Francis C. Lynn, James D. Johnson, Timothy J. Kieffer   +14 more
doaj   +1 more source

Phosphorylation controls autoinhibition of cytoplasmic linker protein-170 [PDF]

, 2010
Author Posting. © American Society for Cell Biology, 2010. This article is posted here by permission of American Society for Cell Biology for personal use, not for redistribution. The definitive version was published in Molecular Biology of the Cell 21
Lee, Ho-Sup, Jeffrey van Haren, Schober, J.M. (Joseph), Borisy, G.G. (Gary), Ho-sup Lee, Komarova, Y. (Yulia), John G. Peloquin, Borisy, Gary G, Danciu, O. (Oana), Nadezhdina, Elena S., van Haren, Jeffrey, Gary G. Borisy, Steven P. Gygi, Akhmanova, A.S. (Anna), van Haren, Jeffrey; id_orcid, Peloquin, J.G. (John), Galjart, Niels; id_orcid, Niels Galjart, Nadezhdina, E. (Elena), Nadezhdina, Elena S, Anjum, R. (Rana), Yulia A. Komarova, Joseph M. Schober, Komarova, Yulia A, Borisy, Gary G., Rana Anjum, Elena S. Nadezhdina, Oana Danciu, Haren, J.A.J. (Jeffrey) van, Anna Akhmanova, Peloquin, John G, Peloquin, John G., Anjum, Rana, Gygi, Steven P., Lee, H.S. (Hahn), Galjart, N.J. (Niels), Schober, Joseph M, Gygi, Steven P, Komarova, Yulia A., Schober, Joseph M., Danciu, Oana, Galjart, Niels, Gygi, S.P. (Steven), Akhmanova, Anna   +43 more
core   +1 more source

Magnetically Actuated Microrobot for Drug Delivery: Current Progress and Challenges

Advanced Robotics Research, EarlyView.
Magnetically actuated microrobots are reshaping targeted drug delivery through wireless propulsion, programmable materials, and localized therapeutic release. This review examines how fabrication, body material selection, structural architecture, loading mechanisms, and imaging‐guided control converge to enable microrobotic therapies while identifying ...
Yang Yang, David J. Cappelleri
wiley   +1 more source

Apelin modulates inflammation and leukocyte recruitment in experimental autoimmune encephalomyelitis

Nature Communications
Demyelination due to autoreactive T cells and inflammation in the central nervous system are principal features of multiple sclerosis (MS), a chronic and highly disabling human disease affecting brain and spinal cord.
Hongryeol Park, Jian Song, Hyun-Woo Jeong, Max L. B. Grönloh, Bong Ihn Koh, Esther Bovay, Kee-Pyo Kim, Luisa Klotz, Patricia A. Thistlethwaite, Jaap D. van Buul, Lydia Sorokin, Ralf H. Adams   +11 more
doaj   +1 more source

Simulation Frameworks for Morphogenetic Problems

Computation, 2015
Morphogenetic modelling and simulation help to understand the processes by which the form and shapes of organs (organogenesis) and organisms (embryogenesis) emerge.
Simon Tanaka
doaj   +1 more source

Dynamics of Multicellular Aggregation and Disaggregation: Implications for Tissue Engineering and Cancer Metastasis [PDF]

, 2010
Epithelial tissues play an important physiological role. Tightly cohesive epithelial sheets form protective barriers that line organs, and in addition, fold into a wide variety of complex 3D architectures with specialized functions.
Pope, Melissa Davis
core   +1 more source

NeuroSuite for Long‐Term Functional and Structural Studies of Air‐Liquid Interface Cerebral Organoids

Advanced Science, EarlyView.
NeuroSuite provides a modular hardware‐software platform integrating Neuroweb and NeuroMaps to enable long‐term, in situ electrophysiological interrogation of air–liquid interface organoid slices while preserving tissue architecture. Its components can be used together or independently to capture real‐time activity, spatial network dynamics, and ...
Belquis Haider, Sagnik Middya, Daniel J. Lloyd‐Davies‐Sánchez, Nino F. Läubli, Sulay Vora, Jakob Träuble, Rohan N. Krajeski, Yuqing Feng, Daniel Duncko, Josiah S. Riley, Rubén Ruiz‐Mateos Serrano, Ole Paulsen, Madeline A. Lancaster, George G. Malliaras, Gabriele S. Kaminski Schierle   +14 more
wiley   +1 more source