Results 131 to 140 of about 27,788 (185)

Reduction of 2-hydroxy-3-arylmorpholines to 3-aryl morpholines

Tetrahedron, 2020
2-Hydroxy-3-aryl morpholines are readily prepared from arylboronic acids, aqueous glyoxal, and 1,2-aminoethanols by a variant of the Petasis borono-Mannich reaction.
S. Wright, Brittany F Simpson, Gary M. Chinigo, Matthew A. Perry, R. Maguire   +4 more
semanticscholar   +1 more source

Lowering Lipophilicity by Adding Carbon: One-Carbon Bridges of Morpholines and Piperazines.

Journal of Medicinal Chemistry, 2018
In this article, we report our investigation of a phenomenon by which bridging morpholines across the ring with one-carbon tethers leads to a counterintuitive reduction in lipophilicity.
S. Degorce, M. Bodnarchuk, I. Cumming, James S. Scott   +3 more
semanticscholar   +1 more source

Photocatalytic Synthesis of Substituted 2-Aryl Morpholines via Diastereoselective Annulation.

Journal of the American Chemical Society
Morpholines are prevalent in medicinal chemistry due to their favorable pharmacokinetic properties and widespread presence in FDA-approved drugs. Existing methods for morpholine synthesis often require prefunctionalized or protected reagents, limiting ...
Tiffany A Brisco, Simon De Kreijger, Vaishnavi N Nair, L. Troian‐Gautier, U. Tambar   +4 more
semanticscholar   +1 more source

Green Synthesis of Morpholines via Selective Monoalkylation of Amines.

Journal of the American Chemical Society
Morpholines are common heterocycles in pharmaceutical and agricultural products, yet methods to synthesize them from 1,2-amino alcohols are inefficient.
Kacey G Ortiz, Andrew T Brusoe, Jason An, Eugene Chong, Lifen Wu   +4 more
semanticscholar   +1 more source

Access to N-α-quaternary chiral morpholines via Cu-catalyzed asymmetric propargylic amination/desymmetrization strategy.

Science Bulletin
Morpholines are widespread in many biologically and catalytically active agents, thus being an important aim of pharmaceutical and synthetic chemists.
Peng Chen, Mao-Mao Zhang, Li Rao, Yuan-Heng Li, Yue Jia, Ying Tan, Wen‐Jing Xiao, Liang‐Qiu Lu   +7 more
semanticscholar   +1 more source

Selective, Catalytic, and Dual C(sp3)-H Oxidation of Piperazines and Morpholines under Transition-Metal-Free Conditions.

Journal of Organic Chemistry, 2018
By using cheap and innocuous reagents, such as NaClO2, NaOCl, and catalytic amounts of TEMPO, a new environmentally friendly protocol for the selective and catalytic TEMPO C(sp3)-H oxidation of piperazines and morpholines to 2,3-diketopiperazines (2,3 ...
Delfino Chamorro‐Arenas, Urbano Osorio-Nieto, L. Quintero, L. Hernandez-Garcia, Fernando Sartillo‐Piscil   +4 more
semanticscholar   +1 more source

Molecular dynamics study of morpholines at water – Carbon dioxide interfaces

Fluid Phase Equilibria, 2019
Strong international focus on measures aiming to mitigate the emission of carbon dioxide into the atmosphere call for efficient solutions feasible for a wide range of CO2 sources.
Juri Selv̊ag, T. Kuznetsova, B. Kvamme
semanticscholar   +1 more source

Organocatalytic Desymmetric Double Aza-Michael Addition Cascade: Enantioselective Synthesis of Fused Morpholines.

Organic Letters
Double aza-Michael addition (DAM) has become an emerging strategy for the construction of two carbon-nitrogen bonds in a single step, which can significantly simplify the synthesis of N-heterocycles.
Sachin S Gorad, P. Ghorai
semanticscholar   +1 more source

A One-Pot Reaction toward the Diastereoselective Synthesis of Substituted Morpholines.

Organic Letters, 2018
The diastereoselective synthesis of various substituted morpholines has been achieved from vinyloxiranes and amino-alcohols under sequential Pd(0)-catalyzed Tsuji-Trost/Fe(III)-catalyzed heterocyclization.
T. Aubineau, J. Cossy
semanticscholar   +1 more source

Morpholine-2,5-dione

Acta Crystallographica Section C Crystal Structure Communications, 2006
In the title compound, C4H5NO3, the morpholine ring adopts a boat conformation that is distorted towards twist-boat, the boat ends being the two Csp3 atoms of the ring. The molecular packing is stabilized by the establishment of strong intermolecular NH...OC hydrogen bonds, which give rise to centrosymmetric dimers, and a network of weak CH2...OC ...
Meritxell, Martínez-Palau, Lourdes, Urpí, Xavier, Solans, Jordi, Puiggalí   +3 more
openaire   +2 more sources