Results 151 to 160 of about 18,579 (227)

Ligand‑Based Virtual Screening Discovery of Thienopyrimidinone Derivatives as Allosteric nSMase2 Modulators and Antivirals Against West Nile Virus

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
Ligand‐based virtual screening of over five million compounds identifies a thienopyrimidinone hit as a novel allosteric nSMase2 modulator. Structure‐guided optimisation improves inhibitory potency and delivers derivatives with antiviral activity against West Nile virus, expanding the chemical space of nSMase2 inhibitors and supporting host‐directed ...
Hadrián Álvarez‐Fernández, Patricia Mingo‐Casas, Ana‐Belén Blázquez, Flavia Caridi, Miguel A. Martín‐Acebes, María‐Jesús Pérez‐Pérez, Eva‐María Priego   +6 more
wiley   +1 more source

PMO's protective wrap: Unraveling its surfactant-mediated stabilization for next-generation antisense therapies. [PDF]

Mol Ther Nucleic Acids
Sharma SN, Gupta A, Sinha S.
europepmc   +1 more source

Convergence of Competitive Azidation, Elimination vs Substitution, and Preferential Ring Formation: Metal-Free, One-Pot Route to Oxa-Ring Fused Triazoles from Functionalized Polyols. [PDF]

ACS Omega
Maiti R, Pathak T.
europepmc   +1 more source

Short Scalable Route to Bis-morpholine Spiroacetals and Oxazepane Analogues: Useful 3D-Scaffolds for Compound Library Assembly. [PDF]

J Org Chem
Kovari D, Male L, Roper KA, Mang CP, Kunz O, Cox LR.   +5 more
europepmc   +1 more source

Influenza Antiviral Prescriptions in the US Inpatient and Outpatient Settings During the 2015-2022 Influenza Seasons. [PDF]

Influenza Other Respir Viruses
Lee K, Basu A, Englund JA.
europepmc   +1 more source

Conditional Localization Pharmacology Manipulates the Cell Cycle with Spatiotemporal Precision. [PDF]

J Am Chem Soc
Deng C, Lan YC, Chen GY, Ekeabu CS, Doan Q, Chung M, Lampson MA, Chenoweth DM.   +7 more
europepmc   +1 more source

Short Communication: The Peripheral Cannabinoid CB₁ Receptor Antagonist AM6545 Modifies Cardiovascular Effects of Endocannabinoids in DOCA-Salt Rats. [PDF]

Int J Mol Sci
Remiszewski P, Schlicker E, Grzęda E, Weresa J, Toczek M, Malinowska B.   +5 more
europepmc   +1 more source

Therapeutic Potential of GYY4137 in Reducing Oxidative Stress and Mortality in Experimental Decompression Sickness. [PDF]

Sci Rep
Daubresse L, Marlinge M, Lavner H, Dodivers JS, Bertaud A, Lledo S, Conte S, Fromonot J, Gastaldi M, Risso JJ, Rostain JC, Blatteau JE, Vallee N, Guieu R, Guieu R.   +14 more
europepmc   +1 more source

Coumarin linker facilitates regulation of CRISPR/Cas9 activity using visible light. [PDF]

RSC Adv
McClain I, Pandit B, Royzen M.
europepmc   +1 more source

Determination of Morpholine

Journal of AOAC INTERNATIONAL, 1940
openaire   +1 more source