Results 141 to 150 of about 18,579 (227)

Viral kinetics in adults with Covid-19 treated with nirmatrelvir-ritonavir or molnupiravir: a population-based, observational cohort study. [PDF]

Virol J
Prager M, Ensle D, Eser H, Glötzl F, Riedl B, Szell M, Valipour A, Zoufaly A, Wenisch C, Haider D, Burgmann H, Thalhammer F, Götzinger F, Jilma B, Karnthaler U, Zeitlinger M, Jorda A.   +16 more
europepmc   +1 more source

Design, Synthesis, Biological Studies and Putative Binding Mode of Novel Benzotriazolothalidomide Derivatives as Cereblon Ligands

Chemical Biology &Drug Design, Volume 108, Issue 3, September 2026.
We narrated the identification of benzotriazole‐based cereblon ligands for their potential use either in PROTAC or CELMoD chemical space, through systematic design and SAR studies, synthesis, biological, and docking experiments resulting in a non‐cytotoxic, potent, drug‐like compound 13, offering scope for optimization to yield an in vivo efficacious ...
Pramit Ganguly, Mrinalkanti Kundu, Tonmoy Sarkar, Gillian Dcosta, Kankana Banerjee, Ritama Banerjee, Arun K. Hajra, Sk Sahabuddin, Sohini Basu, Avratanu Das, Suparna Das, Rajib Barik, Md Ashif Ali   +12 more
wiley   +1 more source

<i>In vitro</i> susceptibility and provisional epidemiological cutoff values for eight antifungal agents against <i>Trichophyton mentagrophytes</i> and <i>Trichophyton interdigitale</i>: a multicenter study from China. [PDF]

J Clin Microbiol
Zheng H, Xie W, Song Y, Cao C, Fu M, Dong B, Wang X, Kong X, Ge N, Mei H, Li R, Pan K, Guo Y, Tong Z, Abliz P, She X, Liu W, Liang G, Li X.   +18 more
europepmc   +1 more source

Targeting PIKfyve: Chemical Biology and Drug Discovery Insights

Chemical Biology &Drug Design, Volume 108, Issue 3, September 2026.
PIKfyve inhibitors have progressed from niche chemical probes to powerful tools for interrogating endolysosomal biology, enabled by rapid and robust cellular phenotypes. Compounds such as apilimod establish PIKfyve as a druggable lipid kinase, while agents like vacuolin‐1 underscore the importance of distinguishing true target engagement from ...
Athavan Alias Anand Selvam, Anamika Sharma   +1 more
wiley   +1 more source

Roles of Ceramide Glucosyltransferase in Controlling Cerebral Microvascular Endothelial Integrity and Angiogenesis Post-Ischemia/Reperfusion. [PDF]

Transl Stroke Res
Mohamud Yusuf A, Zafar M, Hagemann N, Brockmeier U, Schumacher F, Kleuser B, Tertel T, Giebel B, Gulbins E, Hermann DM.   +9 more
europepmc   +1 more source

Synthesis, Structural Characterization, and Investigation of Biological Effects of Novel Benzothiazole‐Triazole Derivatives Designed as AKT Kinase Inhibitors

Chemical Biology &Drug Design, Volume 108, Issue 3, September 2026.
Novel benzothiazole‐triazole derivatives were designed and synthesized as potential anticancer agents targeting the PI3K/Akt pathway. Compound 5h exhibited potent Akt1 inhibition, induced apoptosis and mitochondrial dysfunction in MCF‐7 cells, and demonstrated stable binding in molecular docking and dynamics studies, highlighting its promise for breast
Bilge Çiftçi, Zeynep Gülenç, Büşra Korkut Çelikateş, Derya Osmaniye   +3 more
wiley   +1 more source

The Therapeutic Potential of Purmorphamine Across Disease Models

Journal of Cellular and Molecular Medicine, Volume 30, Issue 17, September 2026.
ABSTRACT Purmorphamine (PUR) is a trisubstituted purine compound that selectively activates Smoothened receptor, thereby initiating Sonic Hedgehog (Shh) signalling—a pathway critical for embryonic patterning, neuronal specification and tissue regeneration across multiple organ systems. Dysregulation of Shh signalling has been implicated in degenerative
Ashis Dhar, Ahnaf Dil Sharar, Saikarthik Papisetty, Mohammad Bydon, F. M. Moinuddin   +4 more
wiley   +1 more source

Netupitant versus aprepitant: model-predicted neurokinin-1 receptor occupancy and implications for long-delayed nausea and vomiting prevention. [PDF]

Support Care Cancer
Iihara H, Bianchini G, Aapro M, Licata L, Bernareggi A, Navari RM, Park YH, Jordan K, Vidal M, Scotté F, Roeland EJ, Schwartzberg L, Rugo HS.   +12 more
europepmc   +1 more source

From Fragments to Function: Novel Hydrazone Derivatives as Monoamine Oxidase Inhibitors

ChemMedChem, Volume 21, Issue 16, 27 August 2026.
Twelve N‐acylhydrazone derivatives (5a–f, 6a–f) were synthesized and characterized. Compounds displayed potent submicromolar inhibition against both MAO‐A and MAO‐B. Compound 6e exhibited the strongest activity (IC50 = 0.073 μM for MAO‐A; 0.064 μM for MAO‐B). Kinetic and docking analyses confirmed reversible, competitive inhibition via FAD interaction.
Hasan Erdinç Sellitepe, Ahmet Buğra Aksel, Ezgi Pehlivanlar Yavrucu, Hilal Zıvalı, Begüm Nurpelin Sağlık Özkan, İnci Selin Doğan   +5 more
wiley   +1 more source

Genetic Background Modulates Zoliflodacin and Gepotidacin Cross-Resistance and Fitness in Neisseria gonorrhoeae. [PDF]

J Infect Dis
Mukherjee A, Blomqvist SOP, Helekal D, Das AA, Palace SG, Grad YH.   +5 more
europepmc   +1 more source