Results 91 to 100 of about 2,660,963 (277)

Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin

Molecular Oncology, EarlyView.
The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla, Jan Kosla, Magdalena Prechova, Lukas Frick, Patricia Bortel, Yasmin Borutzki, Andrea Bileck, Christopher Gerner, Samuel M. Meier‐Menches, Selma Osmanagic‐Myers, Martin Gregor   +10 more
wiley   +1 more source

Astrocyte morphology

Trends in Cell Biology
Astrocytes are predominant glial cells that tile the central nervous system (CNS). A cardinal feature of astrocytes is their complex and visually enchanting morphology, referred to as bushy, spongy, and star-like. A central precept of this review is that such complex morphological shapes evolved to allow astrocytes to contact and signal with diverse ...
Baldwin, Katherine T, Murai, Keith K, Khakh, Baljit S   +2 more
openaire   +4 more sources

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Evaluation of morphological characteristics of tomato accessions at the National Plant Genebank in Vietnam

Technology in Horticulture
The present study aims to evaluate the morphological characteristics of 50 tomato accessions conservating at the National Plant Genebank of Vietnam at Plant Resources Center (PRC), located in An Khanh commune, Hoai Duc district, Hanoi City in the spring ...
Tuyet Anh Thi Vuong, Doan Thi Nguyen, Phuc Tam Thi Nguyen, Nga Thi Hoang, Chi Linh Vu   +4 more
doaj   +1 more source

Philosophical Morphology

Disputatio philosophica : International Journal on Philosophy and Religion, 2009
In the paper authors present, examine, and test elements of the vital idea of the philosophical morphology as a method and a technique of philosophical investigation. The paper consists of some applications mostly concerning the method applied by L. Wittgenstein in PI and related later works, and of a series of examples concerning daily phenomena.
Lukin, Josip, Krkač, Kristijan
openaire   +3 more sources

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Morphological, yield and quality variability among the accessions of Plumbago zeylanica

Electronic Journal of Plant Breeding, 2017
Forty two accessions of Plumbago zeylanica were collected and evaluated for morphological, yield and quality traits. The results revealed that the accession Pz 27 registered the highest mean value for plant height (178.33cm) and fresh weight of root (518.
L. Nalina, K. Shanthanu, K. Rajamani, A. John Joel, Tushar Dhanani, Raghuraj Singh and, Satyanshu Kumar   +6 more
doaj   +1 more source

Morphological Analysis as Classification: an Inductive-Learning Approach

, 1996
Morphological analysis is an important subtask in text-to-speech conversion, hyphenation, and other language engineering tasks. The traditional approach to performing morphological analysis is to combine a morpheme lexicon, sets of (linguistic) rules ...
Bosch, Antal van den, Daelemans, Walter, Weijters, Ton   +2 more
core   +2 more sources

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source