Results 51 to 60 of about 2,701,117 (260)

Ultrafine Metallic Particles as Inducers of Digestive Processes in Rumen: Dry Matter Digestibility of Feed and Enzymatic Activity

Scientifica
The ban on the use of antibiotics in animal husbandry encourages an active search for highly effective alternatives with additional properties, one of which is ultrafine particles (UFP) of metallic nature.
Daniil E. Shoshin, Elena A. Sizova, Elena V. Yausheva, Kristina V. Ryazantseva, Kseniya S. Nechitajlo, Aina M. Kamirova   +5 more
doaj   +1 more source

Phosphoinositide 3-kinase is associated to the nucleus of HL-60 cells and is involved in their ATRA-induced granulocytic differentiation

European Journal of Histochemistry, 2009
Phosphoinositide 3-kinases (PI 3-kinases), a class of enzymes implicated in growth factor-induced mitogenic response and many other intracellular signalling pathways, act by phosphorylation at the D-3’-OH position of the myo-inositol ring of ...
M. Marchisio, L.M. Neri, F. Brugnoli, A. Gonelli, V. Bertagnolo   +4 more
doaj   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

SIMULTANEOUS IDENTIFICATION OF VESSELS AND MAST CELLS BY DOUBLE IMMUNOSTAINING IN GASTRIC MALIGNANT TUMORS [PDF]

Research and Clinical Medicine, 2018
Objective. To assess the microvessel and mast cell density in gastric tumors, and to evaluate the possible correlation between them. Material and method.
PUSA NELA GAJE, RALUCA CEAUSU, SIMONA SARB   +2 more
doaj  

Preconditioning of Human Dental Pulp Stem Cells with Leukocyte- and Platelet-Rich Fibrin-Derived Factors Does Not Enhance Their Neuroregenerative Effect

Stem Cells International, 2019
Pathologies of the central nervous system are characterized by loss of brain tissue and neuronal function which cannot be adequately restored by endogenous repair processes.
Pascal Gervois, Jessica Ratajczak, Esther Wolfs, Tim Vangansewinkel, Yörg Dillen, Greet Merckx, Annelies Bronckaers, Ivo Lambrichts   +7 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

The Neurovascular Properties of Dental Stem Cells and Their Importance in Dental Tissue Engineering

Stem Cells International, 2016
Within the field of tissue engineering, natural tissues are reconstructed by combining growth factors, stem cells, and different biomaterials to serve as a scaffold for novel tissue growth.
Jessica Ratajczak, Annelies Bronckaers, Yörg Dillen, Pascal Gervois, Tim Vangansewinkel, Ronald B. Driesen, Esther Wolfs, Ivo Lambrichts, Petra Hilkens   +8 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

The Therapeutic Effect of Antitumor Drugs Erufosine and Doxorubicin on the Metastatic Process in the Testes of Hamsters with Graffi Myeloid Tumor. Morphometric and Histological Studies

Клиническая онкогематология
Aim. The goal of the current study is directed to investigate the therapeutic effect of erufosine (ЕРС3) alone, as well as in combination with doxorubicin (DOX) on the development of metastases in the testes in an experimental model of transplantable ...
Iliana Najdenova Ilieva, I. V. Sainova, R. A. Toshkova, A. K. Georgieva, V. N. Nanev, R. D. Tzoneva   +5 more
doaj   +1 more source