Results 81 to 90 of about 1,090,581 (353)

Comparative Analysis Of Zebrafish And Planarian Model Systems For Developmental Neurotoxicity Screens Using An 87-Compound Library [PDF]

, 2019
There is a clear need to establish and validate new methodologies to more quickly and efficiently screen chemicals for potential toxic effects, particularly on development. The emergence of alternative animal systems for rapid toxicology screens presents
Collins, Eva-Maria S., Hagstrom, D., Tanguay, R., Truong, L., Zhang, S.   +4 more
core   +1 more source

Survivin and Aurora Kinase A control cell fate decisions during mitosis

Molecular Oncology, EarlyView.
Aurora A interacts with survivin during mitosis and regulates its centromeric role. Loss of Aurora A activity mislocalises survivin, the CPC and BubR1, leading to disruption of the spindle checkpoint and triggering premature mitotic exit, which we refer to as ‘mitotic slippage’.
Hana Abdelkabir, Shalitha Wickrama Arachchige, Sally P. Wheatley   +2 more
wiley   +1 more source

TXNIP upregulation controls metabolism and cell cycle during androgen deprivation therapy in prostate cancer

Cell Death and Disease
Thioredoxin-Interacting Protein (TXNIP) is an arrestin at the crossroad of redox and glycolytic metabolisms. Prostate cancer (PCa) exhibits a unique metabolic profile due to the glycolytic nature of healthy prostate tissue.
Sergio Alcon-Rodriguez, Juan C. Mayo, Pedro Gonzalez-Menendez, Iván Fernandez-Vega, David Hevia, Sheila Fernandez-Vega, Alba Moran-Alvarez, Daniela Pineda-Cevallos, Miguel Alvarez-Mugica, Pablo Rodriguez-Gonzalez, Belen Garcia-Soler, Jorge Zamora, Jose M. C. Tubio, Rosa M. Sainz, Isabel Quiros-Gonzalez   +14 more
doaj   +1 more source

Co-expression networks in generation of induced pluripotent stem cells. [PDF]

, 2016
We developed an adenoviral vector, in which Yamanaka's four reprogramming factors (RFs) were controlled by individual CMV promoters in a single cassette (Ad-SOcMK). This permitted coordinated expression of RFs (SOX2, OCT3/4, c-MYC and KLF4) in a cell for
Coppola, Giovanni, Dansithong, Warunee, Figueroa, Karla P, Gao, Fuying, Paul, Sharan, Pflieger, Lance, Pulst, Stefan M   +6 more
core   +2 more sources

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

Loss of the Extracellular Matrix Molecule Tenascin-C Leads to Absence of Reactive Gliosis and Promotes Anti-inflammatory Cytokine Expression in an Autoimmune Glaucoma Mouse Model

Frontiers in Immunology, 2020
Previous studies demonstrated that retinal damage correlates with a massive remodeling of extracellular matrix (ECM) molecules and reactive gliosis. However, the functional significance of the ECM in retinal neurodegeneration is still unknown.
Susanne Wiemann, Jacqueline Reinhard, Sabrina Reinehr, Zülal Cibir, Stephanie C. Joachim, Andreas Faissner   +5 more
doaj   +1 more source

THE ART OF WAR: PATTERNS AND MECHANISMS UNDERLYING PREDATOR-INDUCED PLASTICITY OF AMPHIBIANS [PDF]

, 2013
Organisms often employ phenotypic plasticity as a strategy to cope with variable environments. This is particularly true of predation threats, wherein prey induce defenses to reduce detection or capture by predators.
Relyea, Rick A, Shaffery, Heather M
core  

Crinoid phylogeny: a preliminary analysis (Echinodermata: Crinoidea) [PDF]

, 2004
We describe the first molecular and morphological analysis of extant crinoid high-level inter-relationships. Nuclear and mitochondrial gene sequences and a cladistically coded matrix of 30 morphological characters are presented, and analysed by ...
Ameziane, N., Cohen, B.L., De Forges, B.R., Eleaume, M.   +3 more
core   +2 more sources

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

USSR Space Life Sciences Digest, issue 6 [PDF]

This is the sixth issue of NASA's USSR Space Life Sciences Digest. It contains abstracts of 54 papers recently published in Russian language periodicals and bound collections and of 10 new Soviet monographs.
Hooke, L. R., Radtke, M., Rowe, J. E., Teeter, R.   +3 more
core   +1 more source