Results 81 to 90 of about 455,228 (309)

Endoglin mediates the tumor‐ and metastasis‐promoting traits of stromal myofibroblasts in human breast carcinomas

Molecular Oncology, EarlyView.
Carcinoma‐associated fibroblasts (CAFs) in tumors influence cancer progression. We identified endoglin (ENG) as a key factor in TGF‐β signaling in myofibroblastic CAFs (myCAFs), linked to poor breast cancer outcomes. Inhibiting ENG on myCAFs suppressed the TGF‐β‐Smad2/3 pathway, reducing primary tumor growth and metastasis.
Shoki Okubo, Yoshihiro Mezawa, Zixu Wang, Ahmet Acar, Yasuhiko Ito, Atsushi Takano, Yohei Miyagi, Tomoyuki Yokose, Toshinari Yamashita, Yataro Daigo, Takuya Shirakihara, Akira Orimo   +11 more
wiley   +1 more source

Targeting carbonic anhydrase IX/XII prevents the anti‐ferroptotic effect of stromal lactic acid in prostate carcinoma

Molecular Oncology, EarlyView.
In prostate carcinoma, lactic acid, secreted by highly glycolytic cancer‐associated fibroblasts, is imported into tumor cells through the MCT1 transporter and prevents RSL3 and erastin‐induced ferroptosis (A). Targeting of carbonic anhydrase IX/XII, the main extracellular pH regulators, in tumor and stromal cells reduces microenvironmental acidosis and
Elisa Pardella, Giuseppina Comito, Luigi Ippolito, Erica Pranzini, Marta Iozzo, Giulia Gangarossa, Francesca Virgilio, Silvia Bua, Alessio Nocentini, Giada Sandrini, Nicla Lorito, Marina Bacci, Gabriella Nesi, Pietro Spatafora, Sergio Serni, Claudiu T. Supuran, Andrea Morandi, Paola Chiarugi, Elisa Giannoni   +18 more
wiley   +1 more source

Beneficial Bacteria Associated With Silica Nanoparticles for Growth Promotion of Paspalum notatum

Applied and Environmental Soil Science
Plant growth–promoting bacteria (PGPB) can play an essential role as biofertilizers to increase pasture efficiency and reduce the application of agrochemicals.
Amanda Carolina Prado de Moraes, Kathryn Louise Kingsley, Lucas da Silva Ribeiro, Bianca Baccili Zanotto Vigna, Emerson Rodrigues de Camargo, James Francis White, Alessandra Pereira Fávero, Paulo Teixeira Lacava   +7 more
doaj   +1 more source

Exploring the role of cyclin D1 in the pathogenesis of multiple myeloma beyond cell cycle regulation

Molecular Oncology, EarlyView.
Cyclin D1 overexpression altered the cell adhesion pathway, while cyclin D2 upregulation had less impact on pathway enrichment analysis. Multiple myeloma (MM) patients with cyclin D1 overexpression showed reduced CD56 expression and increased circulating tumor cells (CTC) levels, suggesting that cyclin D1 may contribute to MM cell dissemination ...
Ignacio J. Cardona‐Benavides, Sara Cristobal‐Vargas, Cristina De Ramón, Elizabeta A. Rojas, Irena Misiewicz‐Krzeminska, Isabel Isidro, José Juan Pérez, Bruno Paiva, Noemi Puig, Miguel Alcoceba, María‐Victoria Mateos, Luis A. Corchete, Myriam Cuadrado, Norma C. Gutiérrez   +13 more
wiley   +1 more source

Diversity of attachment systems in heelwalkers (Mantophasmatodea) – highly specialized, but uniform

BMC Ecology and Evolution
Background Heelwalkers possess a highly modified tarsal attachment system. All extant species lift the distalmost tarsomere permanently off the substrate and primarily use their euplantulae for locomotion.
Thies H. Büscher, Stanislav N. Gorb, Monika J. B. Eberhard   +2 more
doaj   +1 more source

Global Distribution of Canine Visceral Leishmaniasis and the Role of the Dog in the Epidemiology of the Disease

Pathogens
Visceral leishmaniasis is a disease caused by protozoa of the species Leishmania (Leishmania) infantum (syn = Leishmania chagasi) and Leishmania (Leishmania) donovani, which are transmitted by hematophagous insects of the genera Lutzomyia and Phlebotomus.
Diego Fernandes Vilas-Boas, Eiji Kevin Nakasone Nakasone, Ana Alice Maia Gonçalves, Daniel Ferreira Lair, Diana Souza de Oliveira, Diogo Fonseca Soares Pereira, Geralda Gabriele Silva, Ingrid dos Santos Soares Conrado, Lucilene Aparecida Resende, Maykelin Fuentes Zaldívar, Reysla Maria da Silveira Mariano, Walderez Ornelas Dutra, Miguel Angel Chávez-Fumagalli, Alexsandro Sobreira Galdino, Denise Silveira-Lemos, Rodolfo Cordeiro Giunchetti   +15 more
doaj   +1 more source

RKIP overexpression reduces lung adenocarcinoma aggressiveness and sensitizes cells to EGFR‐targeted therapies

Molecular Oncology, EarlyView.
RKIP, a metastasis suppressor protein, modulates key oncogenic pathways in lung adenocarcinoma. In silico analyses linked low RKIP expression to poor survival. Functional studies revealed RKIP overexpression reduces tumor aggressiveness and enhances sensitivity to EGFR‐targeted therapies, while its loss promotes resistance.
Ana Raquel‐Cunha, Joana Pinheiro, Rui F. Marques, Patrícia Fontão, Diana Cardoso‐Carneiro, Adriana Mendes, Izabela N. F. Gomes, Ana Carolina Laus, Renato J. da Silva‐Oliveira, Rui Manuel Reis, Olga Martinho   +10 more
wiley   +1 more source

Some observations on the biology and morphology of the immature stages of Psychodopygus wellcomei fraiha, shaw and lainson, 1971: (Diptera: psychodidae) [PDF]

, 1972
R. D. Ward
openalex   +1 more source

P461: THE FLT3 RECEPTOR IS INVOLVED IN THE ENDOPLASMIC RETICULUM HOMEOSTASIS AND GLUCOSE METABOLISM STATUS IN ACUTE MYELOID LEUKEMIA

HemaSphere, 2023
Maria Turos Cabal, Ana Maria Sanchez-Sanchez, Noelia Puente-Moncada, Carmen Rodriguez, Federico Herrera, Vanesa Martín   +5 more
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source