Results 71 to 80 of about 110,623 (268)

LRRC4 Orchestrates AP2A1‐Containing Clathrin‐Coated Vesicles to Disrupt Mitochondrial Cristae and Restrict Glioblastoma Progression

Advanced Science, EarlyView.
LRRC4 suppresses GBM by regulating AP2A1‐containing Golgi‐derived clathrin‐coated vesicles. Low LRRC4 allows cytoplasmic AP2A1 to maintain mitochondrial fission‐fusion, MICOS integrity, and OXPHOS, promoting proliferation and invasion. High LRRC4 redirects AP2A1‐containing Golgi‐derived clathrin‐coated vesicles to mitochondria, disrupts MICOS, enhances
Yang Li, Cheng Huang, Liangqi Jiang, Zhen Li, Qing Liu, Minghua Wu   +5 more
wiley   +1 more source

Biomimetic Gradient Hydrogels Regulate Osteochondral Regeneration Microenvironment Remodeling via Spatiotemporal Programming Engineering

Advanced Science, EarlyView.
Electric field‑driven continuous gradient hydrogel GHZF4 achieves spatiotemporal growth factor release, modulates immune microenvironment, angiogenesis and osteochondral differentiation. It realizes cell‑free functional osteochondral repair in rat/rabbit models, offering a promising biomimetic strategy for gradient tissue regeneration.
Xiaolian Niu, Shengzhao Xiao, Di Huang, Xuesong Wang, Yanwei Cao, Xiaodan Sun, Nicholas Dunne, Xiaoming Li   +7 more
wiley   +1 more source

DDSurfer: A Weakly‐Supervised Dual‐Stream Deep Learning Framework for Cortical Surface Reconstruction From Diffusion MRI

Advanced Science, EarlyView.
DDSurfer reconstructs cortical surfaces directly from diffusion MRI without requiring T1‐weighted scans. By fusing complementary microstructural features and learning diffeomorphic deformations, it efficiently generates accurate white matter and pial surfaces, improving geometric fidelity and morphometric reliability across datasets for robust surface ...
Chengjin Li, Wei Zhang, Xi Zhu, Yuqian Chen, Nir A. Sochen, Jarrett Rushmore, Carl‐Fredrik Westin, Yogesh Rathi, Lauren J. O'Donnell, Ofer Pasternak, Fan Zhang   +10 more
wiley   +1 more source

Morphometric and Molecular Identification of Eimeria Bovis and Eimeria Zuernii on Beef Cattle in Lamongan, East Java, Indonesia

Jurnal Medik Veteriner
Lamongan Regency, located in East Java, Indonesia, is a significant center for beef cattle production. Despite its prominence, studies on the identification and differentiation of Eimeria spp. parasites in this region are notably lacking.
Muhammad 'Ahdi Kurniawan, Lucia Tri Suwanti, Mufasirin Mufasirin, Endang Suprihati, Poedji Hastutiek, Kusnoto Kusnoto, Arif Nur Muhammad Ansori, Yulianna Puspitasari, Aswin Rafif Khairullah, Ikechukwu Benjamin Moses, Bima Putra Pratama, Katty Hendriana Priscilia Riwu   +11 more
doaj   +1 more source

A comparative assessment of GPX-1 expression and histomorphometry evaluation in IBD vaccinated and supplemented broiler [PDF]

Iraqi Journal of Veterinary Sciences
This article was designed to investigate the bursa of Fabricius (BF) morphometric and effects of glutathione peroxidase enzyme (GPX-1) in infectious bursal disease vaccinated (IBDV) broiler supplemented with selenium-nanomaterials (Se-NPs).
Noor N. Rafo, Hadil B. Al-Sabaawy
doaj   +1 more source

Solvent Oxidation‐Directed Synthesis of Highly Crystalline Iron Oxide Nanoparticles With Near‐Bulk Magnetization

Advanced Science, EarlyView.
Controlled oxidation of benzyl ether is established as a key synthetic parameter in the thermal decomposition of iron(III) acetylacetonate. Oxygenated solvent species alter precursor coordination and nucleation–growth kinetics, producing highly crystalline, magnetite‐rich nanoparticles with tunable size, controlled morphology, and near‐bulk ...
Lukas Hertle, Valentin Gantenbein, Joaquim Llacer‐Wintle, Mingchen Ma, Ziyu Li, Pu Luo, Zhengwei Tan, Fei Chen, Chen Chen, Chuanyi Wu, Chenxin Gao, Chenyi Zhou, Carlos Franco, Pere Bruna, Josep Puigmartí‐Luis, Xiang‐Zhong Chen, Bradley J. Nelson, Salvador Pané   +17 more
wiley   +1 more source

QRICH1 Disrupts Endoplasmic Reticulum Homeostasis and Amplifies NF‐κB Signaling in Periodontal Ligament Stem Cells to Exacerbate Diabetic Periodontitis

Advanced Science, EarlyView.
QRICH1 has been established as a key factor contributing to impaired osteogenic potential and accelerated apoptosis of PDLSCs in diabetic periodontitis. QRICH1 not only significantly enhances UPR‐associated apoptotic signaling but also amplifies NF‐κB‐mediated inflammatory responses. Its inhibition restores osteogenic capacity and reduces alveolar bone
Han Li, Xiaoyu Yang, He Wang, Yunchun Kuang, Yiyao Hu, Houxuan Li, Shuhong Li, Deping Zeng, Jie Li, Jinlin Song   +9 more
wiley   +1 more source

In Situ Profiling of Nanoscale Strains Uncovers Mechano‐Architectural Predictors of Aging and Osteoarthritis Emergence

Advanced Science, EarlyView.
In situ mechanical loading of osteoarthritis‐prone murine knee joints reveals that spatial alterations in subchondral plate microarchitecture precede cartilage loss and promote a shift from coordinated epiphyseal strain dissipation in healthy joints to focal subchondral strain concentration in osteoarthritis‐prone joints.
Aikta Sharma, Lucinda A. E. Evans, Lucie E. Bourne, Jishizhan Chen, Alissa L. Parmenter, Joseph Brunet, Kamel Madi, Sebastian Marussi, Andrew A. Pitsillides, Peter D. Lee, Katherine A. Staines   +10 more
wiley   +1 more source

Metabolic and morphometric alterations inherent to neuromuscular electric stimulation in the antagonist muscle submitted to ankle joint immobilization

Brazilian Archives of Biology and Technology, 2009
The aim of this work was to investigate the effect of the neuromuscular electrical stimulation (ES) on the metabolic and morfometric profile of the tibialis anterior muscle, antagonist to the soleus muscle which was stimulate, under the joint ...
João Luiz Quagliotti Durigan, Karina Maria Cancelliero, Paula Lima Bosi, Gabriel Borges Delfino, Maria Imaculada de Lima Montebelo, Rinaldo Roberto de Jesus Guirro, Carlos Alberto da Silva, Maria Luiza Ozores Polacow   +7 more
doaj   +1 more source

Human Dental Pulp Stem Cell Secretome Restores Ischemic Stroke–Impaired Motor and Cognitive Functions by Reprogramming Redox and Inflammatory Signaling

Advanced Science, EarlyView.
Human dental pulp stem cell secretome emerges as a cell‐free therapeutic strategy for ischemic stroke by reprogramming redox and inflammatory signaling. hDPSC secretome‐derived antioxidant and immunomodulatory factors suppress the TLR4–NOX–ROS–NF‐κB axis, reduce microglial inflammatory responses and apoptosis, and promote neurogenesis, angiogenesis ...
Kyung‐Joo Seong, Sehoon Park, Sun‐Woong Bae, Daseul Kim, Jin Ho Lee, Won‐Seok Choi, Zee‐Yong Park, Ji‐Yeon Jung, Won‐Jae Kim   +8 more
wiley   +1 more source