Results 181 to 190 of about 1,724,016 (262)

Adult Sex Ratio as a Demographic Feedback Linking Mating Systems, Parental Care, and Evolution

Advanced Science, EarlyView.
Breeding systems are some of the most diverse social behavior, and our team is investigation the evolutionary causes of this diversity. This review summarises our research carried out at the University of Bath. We argue that demographic components of wild populations, especially the adult sex ratio, plays a key role driving breeding system variation ...
Tamás Székely, Oscar G. Miranda
wiley   +1 more source

Cardiovascular Disease Mortality Burden in Singapore From 1990 to 2050: A Forecasting Analysis of GBD 2023 Study. [PDF]

JACC Asia
Haryo Teguh RH, Jauhari SM, Hausenloy DJ, Chan MY, Chew NWS.   +4 more
europepmc   +1 more source

Astrocytic LMP2 Coordinates NF‐κB and TGF‐β1/Smad3 Signaling to Drive Neuroinflammation after Cerebral Ischemia/Reperfusion

Advanced Science, EarlyView.
ABSTRACT Astrocyte reactivity critically shapes neuroinflammatory outcomes after ischemic stroke, yet the upstream regulators governing astrocyte state transitions remain incompletely defined. Here, we identify the immunoproteasome subunit low molecular weight protein 2 (LMP2) as an important modulator of astrocyte functional remodeling following ...
Yanguang Mao, Rulan Ma, Zejing Lin, Huiying Zhao, Yuexian Liu, Yonghe Su, Xu Zhang, Xingyong Chen   +7 more
wiley   +1 more source

Diabetes Mortality in the Post-Pandemic Era: What Recent Global Burden of Disease Data Reveals About COVID-19's Lasting Impact. [PDF]

Epidemiologia (Basel)
Wagh K, Chowell G.
europepmc   +1 more source

Surfaceome Reprogramming of Stemsomes Promotes Lung Cancer Targeting via Potentiated Receptor–Ligand Interactions

Advanced Science, EarlyView.
This study presents a surfaceome‐reprogramming strategy for mutation‐independent lung cancer therapy by repurposing dexamethasone to prime mesenchymal stem cell‐derived nanovesicles. The engineered vesicles leverage multi‐valent interactions mediated by upregulated adhesion proteins, EPHA2, and NOTCH3.
Geunhye Kim, In Ah Kwon, Bo Seop Jeong, Hyo Seon Kim, Joo‐Hwan Park, Sung Jean Park, Sang‐Rae Lee, Youngki Lee, Dongwoo Khang   +8 more
wiley   +1 more source

Understanding Mortality Data: A Step-by-Step Guide to CDC WONDER, Joinpoint Analysis, and Forecasting Models. [PDF]

J Epidemiol Glob Health
Shubietah A, Ruzieh M, Hamed BM, Saife S, Abuelazm M, Elgendy MS, Emara A, Ibrahim A, Awashra A, Gowaily I, AbuBaha M, Shbeitah G, Balbaa E, Rakab MS, Mhanna M.   +14 more
europepmc   +1 more source

ZNF33B Promotes Japanese Encephalitis Virus Infection by Regulating the Stability of M6A‐Modified Trim25 to Control the Autophagy Process

Advanced Science, EarlyView.
Upon JEV infection, ZNF33B recruits METTL14 to stabilize the METTL3‐METTL14 m6A methyltransferase complex, leading to increased m6A modification of host transcripts, including Trim25 mRNA. ZNF33B selectively binds m6A‐modified sites on Trim25 mRNA and accelerates its decay, resulting in reduced TRIM25 protein abundance.
Jian Du, Chunwei Li, Jiyuan Luo, Huizhi Zhang, Jinyan Zhang, Suya Wang, Huanchun Chen, Hongli Xu, Xiangmin Li, Ping Qian   +9 more
wiley   +1 more source

Trends, disparities and projections of pericardial diseases related mortality in the United States: A 1999-2035 analysis using artificial deep neural network. [PDF]

Am Heart J Plus
Abdul Rehman K, Fatima E, Sohail R, Hassan W, Javeid J, Zarlish QM, Aftab S, Hassan IN, Minhas AMK, Khan MS.   +9 more
europepmc   +1 more source

Radiation‐Induced Tumor‐Intrinsic LTβR N‐Glycosylation Suppresses Pyroptosis Through TRIM28‐Mediated PCBP2 SUMOylation to Promote Gastric Cancer Radioresistance

Advanced Science, EarlyView.
Radiotherapy triggers LTβR N‐glycosylation, enhancing its overall protein stability and nuclear retention. This accumulation drives TRIM28‐mediated PCBP2 SUMOylation, suppressing pyroptosis and conferring gastric cancer radioresistance. Therapeutically, a targeted nanoplatform (cRGD‐Lipo@EMD) effectively disrupts this regulatory axis, offering a highly
Weijie Zang, Yunlong Ji, Chunwang Zhou, Xiwen Li, Zhuang Lu, Guangze Zhang, Yu Chen, Wanjiang Xue, Yilin Hu   +8 more
wiley   +1 more source

Epidemiological trends and sex disparities in stroke disability-adjusted life years and mortality in Middle East and North Africa (MENA): An analysis of the Global Burden of Disease Data (1990-2023) with machine learning forecasting to 2050. [PDF]

Medicine (Baltimore)
Khalil I, Wagdy M, Adnan Hashim G, Naeem Kareem H, Alshanqiti A, Hossain MI, Nur N, Akter MM, Ali AA, Al-Badri SG, Akoum A.   +10 more
europepmc   +1 more source