Results 191 to 200 of about 32,817 (302)

Forecasting Under-5 Mortality Rate in Somalia to 2030: a comparative analysis of univariate and multivariate ARIMAX models. [PDF]

Front Public Health
Seiman SMK, Abdi MM, Muse AH, Abdi KM, Dahir KJ, Salah O, Nadarajah S.   +6 more
europepmc   +1 more source

CD4+ Tregs Drive Post‐Ischemic Sprouting Angiogenesis via Endothelial YY1/MAML1 Reactivation

Advanced Science, EarlyView.
ABSTRACT Microvascular complications of diabetes are chronic diseases of small vessels. We previously found that CD4+ regulatory T‐cells (Tregs) are markedly reduced in type 2 diabetes (T2D) after ischemic injury in both mice and humans, and that Treg deficiency in immunodeficient mice impairs vascular regeneration.
Hang Qu, Cheng Kiu Ho, Jitao Liu, Lei Cui, Yangfeng Hou, Cai Liang, Wenchu Ye, Randolph H. L. Wong, Shohei Hori, Bin Zhou, Kathy O. Lui   +10 more
wiley   +1 more source

Understanding Mortality Data: A Step-by-Step Guide to CDC WONDER, Joinpoint Analysis, and Forecasting Models. [PDF]

J Epidemiol Glob Health
Shubietah A, Ruzieh M, Hamed BM, Saife S, Abuelazm M, Elgendy MS, Emara A, Ibrahim A, Awashra A, Gowaily I, AbuBaha M, Shbeitah G, Balbaa E, Rakab MS, Mhanna M.   +14 more
europepmc   +1 more source

Combination Immunotherapy as a Promising Strategy to Overcome Immunotherapy Resistance: From Emergence to Next‐Generation Approaches

Advanced Science, EarlyView.
This review examines emerging combination immunotherapy strategies tailored to distinct tumor microenvironments and highlights next‐generation biomarkers that guide response prediction and treatment personalization. It integrates lessons from unsuccessful trials, addresses toxicity challenges, and outlines approaches for early biomarker discovery and ...
Asmita Pandey, Sudhir Kumar Rai, Li Ma, Lauren Higa, Vedbar Khadka, Hua Yang, Youping Deng   +6 more
wiley   +1 more source

Early-warning prediction of visceral leishmaniasis mortality using a multivariate STL-deep learning hybrid approach on 20 years of monthly time series. [PDF]

Front Public Health
El Guma F, Awadalla M, Al Rawi HZ, Saeed B, Alshanbari HM, Shokeralla AA, Alosaimi B.   +6 more
europepmc   +1 more source

Autoimmune Encephalitis in Acute Care—Pathology, Diagnosis, and Management

Advanced Science, EarlyView.
ABSTRACT Autoimmune encephalitis (AE) is characterized by immune‐mediated inflammation of the brain parenchyma, presenting with various neurological syndromes, including but not limited to seizures, altered consciousness, neuropsychiatric symptoms, and movement disorders.
Suneesh Thilak, David Okoh, William Scotton, Shanika Samarasekera, Vikram Patil, Suresh Renukappa, Andrew Macduff, Subashini Suresh, Rajeev Krishnadas, Tonny Veenith   +9 more
wiley   +1 more source

Sex-stratified epidemiological trajectories and predictive modeling of aortic aneurysm mortality in South Asia: A global burden of disease analysis (1990-2021) with advanced forecasting to 2050. [PDF]

Medicine (Baltimore)
Khalil I, Nisa NA, Nuha MF, Sayed MA, Labib MK, Meem ZT, Akter MM, Hossain MI.   +7 more
europepmc   +1 more source

Humanized and Charge‐Optimized CSPG4‐Specific CAR‐T Cells show Enhanced Efficacy against Head and Neck Squamous Cell Carcinoma

Advanced Science, EarlyView.
CSPG4 is identified as a high‐value, stemness‐associated target in HPV‐negative HNSCC. By implementing rational biophysical engineering, a humanized and charge‐optimized CAR is developed to overcome tonic signaling‐induced exhaustion. This strategy induces a profound transcriptomic shift toward a rejuvenated, stem‐like memory state, significantly ...
Xiang Xu, Shizhen Qiu, Zhitong Wang, Dan Li, Min Chen, Yinying Chu, Guangfei Li, Yi Fang, Changjiang Li, Fang Shi, Peijie He, Haitao Wu, Haopeng Wang, Jian Chen   +13 more
wiley   +1 more source

Regional trends and forecasting of under-five child mortality in Bangladesh: A mixed method approach of Functional ANOVA and Bayesian spatiotemporal modeling. [PDF]

PLoS One
Hossain MI, Uddin MSG, Rahman A, Sarkar S.   +3 more
europepmc   +1 more source

G3BP1 Succinylation at K413 is Critical for Cardiac Function by Modulating PI3K‐AKT‐mTOR Signal Axis

Advanced Science, EarlyView.
Schematic illustrating the impact of G3BP1 succinylation at K413 on cardiac function. In the healthy human heart, G3BP1 succinylation maintains homeostatic mTOR signaling. In patients with dilated cardiomyopathy (DCM) and heart failure (HF), G3BP1 de‐succinylation induces RagA expression and disrupts the binding of the TSC1/2 complex, leading to the ...
Yuan Zhang, Cancan Yao, Yan Chen, Ke Cai, Zhouping Lu, Boxuan Wu, Kun Yu, Yan Shi, Jianyuan Zhao, Xiangyu Zhou   +9 more
wiley   +1 more source