Results 91 to 100 of about 369,180 (307)

Health and economic benefits of building ventilation interventions for reducing indoor PM2.5 exposure from both indoor and outdoor origins in urban Beijing, China [PDF]

open access: yes, 2018
China is confronted with serious PM2.5 pollution, especially in the capital city of Beijing. Exposure to PM2.5 could lead to various negative health impacts including premature mortality. As people spend most of their time indoors, the indoor exposure to
Lin, Yaoyu   +4 more
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

An application of MCMC simulation in mortality projection for populations with limited data

open access: yesDemographic Research, 2014
Objective: IIn this paper, we investigate the use of Bayesian modeling and Markov chain Monte Carlo (MCMC) simulation, via the software WinBUGS, to project future mortality for populations with limited data. In particular, we adapt some extensions of the
Jackie Li
doaj   +1 more source

Lee Carter mortality forecasting: application to the Italian population [PDF]

open access: yes, 2005
In this paper we investigate the feasibility of using the Lee-Carter methodology to construct mortality forecasts for the Italian population. We fit the model to the matrix of Italian death rates for each gender from 1950 to 2000. A time-varying index of
Haberman, S., Russolillo, M.
core  

Childhood mortality in sub-Saharan Africa : cross-sectional insight into small-scale geographical inequalities from Census data [PDF]

open access: yes, 2012
Objectives To estimate and quantify childhood mortality, its spatial correlates and the impact of potential correlates using recent census data from three sub-Saharan African countries (Rwanda, Senegal and Uganda), where evidence is lacking.
Clarke, Aileen   +2 more
core   +1 more source

Molecular cancer prevention: Intercepting disease

open access: yesMolecular Oncology, EarlyView.
Oncological practice must evolve, from treating established tumours to proactive cancer interception before clinical manifestation. This will require mechanistic insight into tumour initiation, validated biomarkers of early disease development and redesigned clinical trials, enabling cancer interception to become a core pillar of oncology with the ...
Charlotte Grieco   +2 more
wiley   +1 more source

Analyzing Temperature Effects on Mortality Within the R Environment: The Constrained Segmented Distributed Lag Parameterization

open access: yesJournal of Statistical Software, 2010
Here we present and discuss the R package modTempEff including a set of functions aimed at modelling temperature effects on mortality with time series data.
Vito M. R. Muggeo
doaj  

Estimating under-recognized COVID-19 deaths, United States, march 2020-may 2021 using an excess mortality modelling approach. [PDF]

open access: yesLancet Reg Health Am, 2021
Iuliano AD   +9 more
europepmc   +1 more source

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