Results 71 to 80 of about 369,180 (307)

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Joint modelling of longitudinal and time-to-event data: an illustration using CD4 count and mortality in a cohort of patients initiated on antiretroviral therapy

BMC Infectious Diseases, 2020
Background Modelling of longitudinal biomarkers and time-to-event data are important to monitor disease progression. However, these two variables are traditionally analyzed separately or time-varying Cox models are used.
Nobuhle N. Mchunu, Henry G. Mwambi, Tarylee Reddy, Nonhlanhla Yende-Zuma, Kogieleum Naidoo   +4 more
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

A Parametric Factor Model of the Term Structure of Mortality

Econometrics, 2019
The prototypical Lee–Carter mortality model is characterized by a single common time factor that loads differently across age groups. In this paper, we propose a parametric factor model for the term structure of mortality where multiple factors are
Niels Haldrup, Carsten P. T. Rosenskjold   +1 more
doaj   +1 more source

Modelling distributed lag effects in mortality and air pollution studies: the case of Santiago [PDF]

, 2001
Most of the epidemiological literature on air pollution and mortality deals only with single or dual pollutant models whose results are hard to interpret and of questionable value from the policy perspective.
Cifuentes, L., Maddison, D.
core  

Emergent global patterns of ecosystem structure and function from a mechanistic general ecosystem model [PDF]

, 2014
Anthropogenic activities are causing widespread degradation of ecosystems worldwide, threatening the ecosystem services upon which all human life depends.
A Friedlander, A Hardisty, B Cho, B Collen, B-E Sæther, BJ McGill, C Mora, C Ward-Paige, CA Deutsch, CB Field, CD Thomas, CEL Ferreira, CH Sekercioglu, CM Duarte, CR McClain, D Griffiths, D Policansky, D Post, D Yates, Derek P. Tittensor, DG Jenkins, Drew W. Purves, DW Purves, E Jeppesen, E Macpherson, E Odum, E Siemann, EA Fulton, FS Chapin, G Krinner, GA Kaufman, GM Mace, H Cyr, H Stibor, HR Peinetti, J Cebrian, J Chase, J Gasol, J Merilä, JA Carton, JE Cohen, JH Brown, JL Frangi, JM Sunday, Jon Hutton, JP Rodríguez, JS Millar, Jörn P. W. Scharlemann, K Rose, KA Nagy, KA Schubert, KE Jones, KR Buck, L Tremblay-Boyer, LLM Fedigan, LW Oring, M Behrenfeld, M González-Suárez, Matthew J. Smith, MBJ Harfoot, ME Power, Michael B. J. Harfoot, Michel Loreau, MJ Coe, MJ Morgan, MJ Smith, MJ Vander Zanden, MK Litvak, MR Evans, MW McCoy, N Blakley, N Loeuille, NG Hairston, O Krüger, P Abrams, P Del Giorgio, PK Holland, R Alkemade, R Bustamante, R Gentile, R Meek, R Shine, R Shine, RE Ricklefs, RE Ricklefs, RJ Williams, RJ Williams, RW Sheldon, RW Wilson, S Díaz, S Fretwell, S Jain, S Jennings, S Jennings, S Meiri, S Sitch, SA Sandin, SD Pletcher, Stephen Emmott, T Newbold, T Sousa, Tim Newbold, TJ Case, TJ Webb, U Brose, V Christensen, Vassily Lyutsarev, W Sprules, X Irigoien, Y-J Shin   +109 more
core   +4 more sources

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Toward trait-based mortality models for tropical forests. [PDF]

PLoS ONE, 2013
Tree mortality in tropical forests is a complex ecological process for which modelling approaches need to be improved to better understand, and then predict, the evolution of tree mortality in response to global change.
Mélaine Aubry-Kientz, Bruno Hérault, Charles Ayotte-Trépanier, Christopher Baraloto, Vivien Rossi   +4 more
doaj   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Modelling stillbirth mortality reduction with the Lives Saved Tool

BMC Public Health, 2017
Background The worldwide burden of stillbirths is large, with an estimated 2.6 million babies stillborn in 2015 including 1.3 million dying during labour.
Hannah Blencowe, Victoria B. Chou, Joy E. Lawn, Zulfiqar A. Bhutta   +3 more
doaj   +1 more source