Results 181 to 190 of about 366,903 (304)

Light Activated Induction of Cuproptosis in Resistant Cancer Cells Using Polymeric BODIPY Nanoparticles for Photoactivated Chemotherapy

Advanced Functional Materials, EarlyView.
This article presents a photo‐responsive nanoparticle platform that precisely triggers copper‐dependent cuproptotic cell death in (drug‐resistant) cancer cells. The system remains stable and inactive in the dark but releases cytotoxic species upon red‐light irradiation, achieving potent activity in drug‐resistant breast cancer cells.
Ricarda Zimmermann, Nicolás Montesdeoca, Johannes Karges   +2 more
wiley   +1 more source

Risk factors for COPD exacerbations and mortality, and variation between primary care settings: the PRAXIS cohort study in Sweden. [PDF]

Fam Med Community Health
Smith C, Hiyoshi A, Arnison T, Eliason G, Giezeman M, Hasselgren M, Janson C, Karlsson M, Kisiel MA, Lisspers K, Nager A, Sandelowsky H, Ställberg B, Sundh J, Montgomery S.   +14 more
europepmc   +1 more source

Metal–Organic Frameworks for Gaseous Pollutant Management: From Capture to Neutralization and Reutilization

Advanced Functional Materials, EarlyView.
This review maps how MOFs can manage hazardous gases by combining adsorption, neutralization, and reutilization, enabling sustainable air‐pollution control. Covering chemical warfare agent simulants, SO2, NOx, NH3, H2S, and volatile organic compounds, it highlights structure‐guided strategies that boost selectivity, water tolerance, and cycling ...
Yuanmeng Tian, Zeyu Tao, Kaikai Ma, Xiaoliang Wang, Bo Yu, Yiu Wan Yip, Zhijie Chen, Jin Shang, Bin Fei   +8 more
wiley   +1 more source

Trends in the burden of road traffic injuries among children and adolescents aged 0-19 years in low- and middle-income countries, 1990-2023. [PDF]

J Glob Health
Song Z, Zhang B, Pang S, Qiu M, Huang J, Hao J, Yang X, Li Y.   +7 more
europepmc   +1 more source

Computational Modeling Meets 3D Bioprinting: Emerging Synergies in Cardiovascular Disease Modeling

Advanced Healthcare Materials, EarlyView.
Emerging advances in three‐dimensional bioprinting and computational modeling are reshaping cardiovascular (CV) research by enabling more realistic, patient‐specific tissue platforms. This review surveys cutting‐edge approaches that merge biomimetic CV constructs with computational simulations to overcome the limitations of traditional models, improve ...
Tanmay Mukherjee, Mehdi Salar Amoli, Sarah Rezapourdamanab, Lama Rita El Shammas, Martin L. Tomov, Emilio A. Mendiola, Vahid Serpooshan, Reza Avazmohammadi   +7 more
wiley   +1 more source

Risk stratification using coronary artery calcium and potential benefit of semaglutide therapy: A cost-effectiveness modelling study. [PDF]

Diabetes Obes Metab
Ponnana SR, Zhang T, Sirasapalli SK, Chen Z, Dazard JE, Surya N, Elhussain S, Sivanantham K, Okyere R, Neeland IJ, Rajagopalan S, Deo SV.   +11 more
europepmc   +1 more source

A 3D Bioprinted Spheroid‐Laden dECM‐Enriched Osteosarcoma Model for Enhanced Drug Testing and Therapeutic Discovery

Advanced Healthcare Materials, EarlyView.
A 3D biomimetic OS model was developed by bioprinting an OS‐cell‐derived dECM‐enriched bioink with OS spheroids incorporated. The model showed upregulation of known OS prognostic markers and increased resistance to doxorubicin, compared to 2D cultures and scaffold‐free spheroids, making this a more clinically relevant platform for drug discovery ...
Margarida F. Domingues, Maria Catarina Carreira, Mafalda S. Santos, Daniela Pacheco, Frederico Castelo Ferreira, Paola Sanjuan‐Alberte, João Carlos Silva   +6 more
wiley   +1 more source

What is the ideal glucose range for a patient with sepsis in the ICU? A retrospective analysis of MIMIC-IV. [PDF]

BMJ Open
Struja T, Hansen LH, Matos J, Gómez J, Pardo A, Lourentzou I, Hejazi N, Celi LA, Waschka AK.   +8 more
europepmc   +1 more source

Targeting the ARRDC3–DRP1 Axis via hUMSC‐Derived Exosomal CRYAB for Neuroprotection in Cerebral Ischemia/Reperfusion Injury

Advanced Healthcare Materials, EarlyView.
Intranasally administered hUMSC‐derived exosomes modulate the CRYAB–ARRDC3–Drp1 axis, alleviating mitochondrial dysfunction and ferroptosis, enhancing neuronal survival, reducing oxidative stress, and promoting functional recovery in ischemia‐reperfusion injury, offering a promising therapeutic strategy for ischemic stroke.
Rong ji, Zengyu Zhang, Zhuohang Liu, Kaicheng Yang, Xueyu Mao, Min Chu, Yong Wang, Jing Zhao   +7 more
wiley   +1 more source

Reply: The AHEAD score in acute myocardial infarction: a call for more rigorous validation. [PDF]

AsiaIntervention
Saji M.
europepmc   +1 more source