Results 261 to 270 of about 3,071,110 (344)

Artesunate Ameliorates APAP‐induced Liver Injury by Promoting NEDD4L‐Mediated Ubiquitination and Degradation of TXNIP

Advanced Science, EarlyView.
ABSTRACT Liver injury can lead to severe acute liver failure and even death in patients. Artesunate (ART), which is a derivative of artemisinin that has been approved by the FDA for the treatment of malaria, has significant regulatory effects on cell death and inflammation.
Zhe Zhang, Hongyi Zhang, Haixiang Guo, Xiwen Zhang, Yidan Wang, Baoyin Wang, Tong Wang, Guokun Zhao, Qing Zhang, Fei Gao, Shuang Liang, Hao Jiang, Yu Ding, Xiliang Du, Jiabao Zhang, Yi Zheng, Xinwei Li, Bao Yuan   +17 more
wiley   +1 more source

Global, regional, and national burden of lower respiratory infections attributable to secondhand smoke exposure: Trends from 1990-2021 and projections to 2035. [PDF]

Chin Med J (Engl)
Zi G, Zhou L, Wang L, Zheng P, Liu X, Wei S.   +5 more
europepmc   +1 more source

National pupil projections : future trends in pupil numbers [PDF]

, 2012
Tuddenham, Fay
core  

Promoter Hypermethylation‐Induced Silencing of FXYD1 Drives Breast Cancer Metastasis via DDX5‐Mediated Wnt/β‐Catenin Pathway Activation

Advanced Science, EarlyView.
This study identifies FXYD1 as an epigenetically silenced tumor suppressor in breast cancer. DNA methylation turns off the gene FXYD1 in breast cancer, and low levels predict worse outcomes. Restoring FXYD1 limits breast cancer cells proliferation and metastasis. In the nucleus, FXYD1 recruits the E3 ligase MAEA to K63‐ubiquitinate DDX5 for proteasomal
Ping Wen, Fanli Qu, Long Wang, Qing Shao, Sisi Li, Yang Qin, Dongping Jiang, Senmiao Zhang, Jiangdong Sui, Guanwen Wang, Ningning Zhang, Xiaohua Zeng   +11 more
wiley   +1 more source

G20 Country Burden of High BMI-Related Liver Cancer: Trends from 1990 to 2021 and Projections to 2050. [PDF]

J Epidemiol Glob Health
Chen Y, Huang M, Huang Y.
europepmc   +1 more source

[Demographic projections (Part 7): problems of projecting mortality].

Wiadomosci statystyczne (Warsaw, Poland : 1956), 1982
openaire   +1 more source

Selective Inhibition of Integrin β3 Topology Provides a Safer Antithrombotic Strategy

Advanced Science, EarlyView.
Current integrin αIIbβ3 inhibitors effectively reduce thrombosis but also increase bleeding risk. During thrombosis, high shear blood flow can directly activate the integrin αIIbβ3 via a distinct topological change in the β3 transmembrane domain, independent of hemostatic platelet signaling.
Joonha Lee, Chul‐Gyun Lim, Pothiappan Vairaprakash, Jong‐Min Kim, Jiyoon Kim, Ji‐Young Park, Klaus M. Hahn, Hyunbo Shim, Hae Woong Choi, Tobias S. Ulmer, Soon Jun Hong, Chungho Kim   +11 more
wiley   +1 more source

Excess mortality of German men and women aged 60 years and older needing long-term care 2020-2024: data from a statutory health insurance comprising more than 3 million people. [PDF]

Front Public Health
Haß L, Wende D, Voß S, Brinks R.
europepmc   +1 more source

Adult Sex Ratio as a Demographic Feedback Linking Mating Systems, Parental Care, and Evolution

Advanced Science, EarlyView.
Breeding systems are some of the most diverse social behavior, and our team is investigation the evolutionary causes of this diversity. This review summarises our research carried out at the University of Bath. We argue that demographic components of wild populations, especially the adult sex ratio, plays a key role driving breeding system variation ...
Tamás Székely, Oscar G. Miranda
wiley   +1 more source

Comparative Modeling of Recent and Projected Trends in the Incidence and Mortality of Uterine Cancer. [PDF]

Obstet Gynecol
Rouse KJ, Hazelton WD, Frotscher A, Chen L, Prest MT, Ferris JS, Xu X, Melamed A, Hur C, Heckman-Stoddard BM, Samimi G, Bickell NA, Layne TM, Blank SV, Elkin EB, Myers ER, Havrilesky LJ, Kong CY, Wright JD.   +18 more
europepmc   +1 more source