Results 81 to 90 of about 2,891,390 (297)

Global burden and projections of breast cancer incidence and mortality to 2050: a comprehensive analysis of GLOBOCAN data

Frontiers in Public Health
BackgroundBreast cancer is a leading global health challenge, exhibiting significant regional disparities in incidence, mortality, and survival outcomes. This study analyzed the burden of breast cancer in 2022 and projects its future impact by 2050 using
Omar Freihat, David Sipos, Arpad Kovacs
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Projecting UK Mortality by Using Bayesian Generalized Additive Models [PDF]

Journal of the Royal Statistical Society Series C: Applied Statistics, 2018
SummaryForecasts of mortality provide vital information about future populations, with implications for pension and healthcare policy as well as for decisions made by private companies about life insurance and annuity pricing. The paper presents a Bayesian approach to the forecasting of mortality that jointly estimates a generalized additive model (GAM)
Hilton, Jason, Dodd, Erengul, Forster, Jonathan J., Smith, Peter W.F.   +3 more
openaire   +7 more sources

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

Molecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic, Anne Nørremølle, Lilian Bomme Ousager, Lars van Brakel Andersen, Marie Louise Mølgaard Binderup, Mads Thomassen   +5 more
wiley   +1 more source

Projecting productivity losses for cancer-related mortality 2011 – 2030 [PDF]

BMC Cancer, 2016
Background: When individuals stop working due to cancer this represents a loss to society - the loss of productivity. The aim of this analysis was to estimate productivity losses associated with premature mortality from all adult cancers and from the 20 highest mortality adult cancers in Ireland in 2011, and project these losses until 2030. Methods: An
Alison Pearce, Cathy Bradley, Paul Hanly, Ciaran O’Neill, Audrey Alforque Thomas, Michal Molcho, Linda Sharp   +6 more
openaire   +4 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Tobacco-related cancer mortality: projections for different geographical regions in Switzerland

Swiss Medical Weekly, 2013
PRINCIPLES: Switzerland is divided into 26 cantons of variable population size and cultural characteristics. Although a federal law to protect against passive smoking and a national tobacco control programme exist, details of tobacco-related ...
Verena Jürgens, Silvia Ess, Harish C. Phuleria, Martin Früh, Matthias Schwenkglenks, Harald Frick, Thomas Cerny, Penelope Vounatsou   +7 more
doaj   +1 more source

Projecting Fine Particulate Matter-related Mortality in East China [PDF]

ISEE Conference Abstracts, 2015
China is suffering from severe air pollution from fine particulate matter [≤ 2.5 μm in aerodynamic diameter (PM2.5)], especially East China. But its future trends and potential health impacts remain unclear. The study objectives were to project future trends of PM2.5 and its short-term effect on mortality in East China by 2030.
Madaniyazi, Lina, Nagashima, Tatsuya, Guo, Yuming, Yu, Vivian (Weiwei), Tong, Shilu   +4 more
openaire   +3 more sources

Heat-related mortality projections for cardiovascular and respiratory disease under the changing climate in Beijing, China

Scientific Reports, 2015
Because heat-related health effects tend to become more serious at higher temperatures, there is an urgent need to determine the mortality projection of specific heat-sensitive diseases to provide more detailed information regarding the variation of the ...
Tiantian Li, J. Ban, R. Horton, D. Bader, Ganlin Huang, Qinghua Sun, P. Kinney   +6 more
semanticscholar   +1 more source

Antibiofilm activity of a chionodracine‐derived peptide by NMR‐based metabolomics of cell‐free supernatant of Acinetobacter baumannii clinical strains

FEBS Open Bio, EarlyView.
KHS‐Cnd peptide is able to impair biofilm formation and disaggregate mature biofilms in Acinetobacter baumannii clinical isolates. Differences in extracellular metabolites reflect changes in biofilm metabolism due to KHS‐Cnd treatment. Among the differentially represented extracellular metabolites upon KHS‐Cnd treatment, the significantly altered ...
Fernando Porcelli, Enrico Landi, Francesco Maiurano, Irene Paris, Rosanna Papa, Marco Artini, Laura Selan, Stefano Borocci, Francesco Buonocore, Esther Imperlini   +9 more
wiley   +1 more source