Results 81 to 90 of about 1,865,481 (313)

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

Molecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou, Athina Markou, Eleonora Nicolo, Mara S Serafini, Qiang Zhang, Youbin Zhang, Lorenzo Gerratana, Andrew A. Davis, Huiping Liu, William J Gradishar, Carolina Reduzzi, Massimo Cristofanilli, Evi Lianidou   +12 more
wiley   +1 more source

Analysis of the standing age distribution and age-specific recruitment rate of the George River and Beverly barren-ground caribou populations

Rangifer, 1991
The primary advantage of the standing age distribution of a population is that it can be sampled. Analysis of the age frequencies for estimates of survival rates and determinations of population status by life table construction depend heavily on ...
M. Taylor
doaj   +1 more source

Are health inequalities really not the smallest in the Nordic welfare states? A comparison of mortality inequality in 37 countries

, 2013
<b>Background:</b> Research comparing mortality by socioeconomic status has found that inequalities are not the smallest in the Nordic countries. This is in contrast to expectations given these countries’ policy focus on equity.
Bambra, C., Popham, Frank, Bambra, Clare, Dibben, Christopher John Lloyd, Dibben, Chris, Dibben, C., Popham, F.   +6 more
core   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Stochastic Mortality, Subjective Survival Expectations, and Individual Saving Behavior [PDF]

Theoretical studies suggest that unexpected changes in future mortality and survival probabilities (stochastic mortality) are important determinants of individuals’ decisions about consumption, saving, asset allocation, and retirement timing.
Katja Hanewald, Thomas Post
core  

Tobacco smoking and all-cause mortality in a large Australian cohort study: findings from a mature epidemic with current low smoking prevalence [PDF]

, 2015
This study finds that up to two-thirds of deaths in current smokers  in Australia can be attributed to smoking. Abstract Background The smoking epidemic in Australia is characterised by historic levels of prolonged smoking, heavy smoking, very ...
Weber, MF, Paige, Ellie, Joshy, Grace, Alan D Lopez, Ellie Paige, Marianne F. Weber, Banks, E, Grenfell, Robert, Sitas, F, Sam Egger, Grenfell, R, Emily Banks, Egger, S, Liu, B ; https://orcid.org/, Paige, E, Valerie Beral, Robert Grenfell, Marianne F Weber, Bette Liu, Lopez, Alan D, Sitas, Freddy, Lopez, AD, Grace Joshy, Joshy, G, Sitas, F ; https://orcid.org/, Liu, Bette, Banks, Emily, Alan D. Lopez, Weber, Marianne F, Freddy Sitas, Beral, Valerie, Liu, B, Beral, V, Egger, Sam   +33 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Executive branch federal civil servant mortality by sex and educational level - 1993/2014

Revista Contabilidade & Finanças
Life tables have been elaborated throughout much of human history. However, the first life table to use actuarial concepts was only constructed in 1815 by Milne for the city of Carlisle in England.
Kaizo Iwakami Beltrão, Sonoe Sugahara
doaj   +1 more source

Unemployment duration tables

Acta Universitatis Lodziensis. Folia Oeconomica, 2016
The purpose of the article is to construct the registered unemployment duration table. The table is a non-parametric model (also called a tabular model) showing the duration of a given phenomenon.
Beata Bieszk-Stolorz, Iwona Markowicz
doaj   +1 more source

The Urban Mortality Transition in the United States, 1800-1940 [PDF]

In the United States in the 19th and early 20th centuries, there was a substantial mortality 'penalty' to living in urban places. This circumstance was shared with other nations.
Michael R. Haines
core