Results 31 to 40 of about 265,712 (265)

Nephrogenic Rests/Nephroblastomatosis in Patients With Unilateral Wilms Tumor Are Not Associated With an Increased Risk of Relapse: An Analysis of Patients Treated on the SIOP‐WT‐2001 Protocol in the SIOP‐UK‐CCLG and SIOP‐GPOH Studies (2001–2022)

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Introduction Nephrogenic rests (NRs) and nephroblastomatosis (NBM) are precursor lesions for development of Wilms tumor (WT). Their association with the risk of relapse has not been properly assessed, partly due to misunderstanding of their diagnostic criteria and terminology.
Gordan M. Vujanić, Rhoikos Furtwängler, Tanzina Chowdhury, Christian Vokuhl, Jenny Wegert, Norbert Graf   +5 more
wiley   +1 more source

Longitudinal In Vivo Assessment of Host-Microbe Interactions in a Murine Model of Pulmonary Aspergillosis

iScience, 2019
Summary: The fungus Aspergillus fumigatus is ubiquitous in nature and the most common cause of invasive pulmonary aspergillosis (IPA) in patients with a compromised immune system. The development of IPA in patients under immunosuppressive treatment or in
Shweta Saini, Jennifer Poelmans, Hannelie Korf, James L. Dooley, Sayuan Liang, Bella B. Manshian, Rein Verbeke, Stefaan J. Soenen, Greetje Vande Velde, Ine Lentacker, Katrien Lagrou, Adrian Liston, Conny Gysemans, Stefaan C. De Smedt, Uwe Himmelreich   +14 more
doaj   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Creating Conditions for Innovation in a Complex Health System: A management practice analysis

Asia Pacific Journal of Health Management
As extended lifespans, rapid technological evolution and rising public expectations are increasing the complexity of our healthcare systems, health leaders need to innovate to gain sustainable improvements.
Sharon Mickan
doaj   +1 more source

Universal characteristics of clip culture

Вестник университета, 2023
The article analyzes the phenomenon of clip culture. Alvin Toffler’s information society dynamics concept has become the methodological basis of the research.
A. P. Avdeeva, Yu. A. Safonova
doaj   +1 more source

Mosaics and moles [PDF]

European Journal of Human Genetics, 2011
Hydatidiform mole (HM) is an abnormal human pregnancy, where the placenta presents with vesicular swelling of the chorionic villi. A fetus is either not present, or malformed and not viable. Most moles are diploid androgenetic as if one spermatozoon fertilized an empty oocyte, or triploid with one maternal and two paternal chromosome sets as if two ...
Sunde, Lone; id_orcid 0000-0002-8479-165X, Niemann, Isa, Hansen, Estrid Staehr, Hindkjaer, Johnny, Degn, Birte, Jensen, Uffe Birk; id_orcid 0000-0002-6205-6355, Bolund, Lars   +6 more
openaire   +3 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Somatic Mosaicism of a PDGFRB Activating Variant in Aneurysms of the Intracranial, Coronary, Aortic, and Radial Artery Vascular Beds

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2022
Background Activating variants in platelet‐derived growth factor receptor beta (PDGFRB), including a variant we have previously described (p.Tyr562Cys [g.149505130T>C [GRCh37/hg19]; c.1685A>G]), are associated with development of multiorgan pathology ...
Carolina A. Parada, Fatima M. El‐Ghazali, Daphne Toglia, Jacob Ruzevick, Malia McAvoy, Samuel Emerson, Yigit Karasozen, Tina Busald, Ahmad A. Nazem, Shaun M. Suranowitz, Sherene Shalhub, Desiree A. Marshall, Luis F. Gonzalez‐Cuyar, Michael O. Dorschner, Manuel Ferreira   +14 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source