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Prenatal Life is the Predominant Source of Somatic Mosaicism Across Tissues and Aging
Verdin E +5 more
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Inherent mosaicism and extensive mutation of human placentas
Nature, 2021 Tim H H Coorens +2 more
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Human Reproduction Update, 2021 BACKGROUND Chromosomal mosaicism can be detected in different stages of early life: in cleavage stage embryos, in blastocysts and biopsied cells from blastocysts during preimplantation genetic testing for aneuploidies (PGT-A) and later during prenatal ...
Geerke M Eggenhuizen +2 more
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Genetic mosaicism in the human brain: from lineage tracing to neuropsychiatric disorders
Nature Reviews Neuroscience, 2022Sara Bizzotto, Christopher A Walsh
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Chromosomal mosaicism in human blastocysts: the ultimate diagnostic dilemma
Human Reproduction Update, 2020 BACKGROUND Trophectoderm (TE) biopsy and next generation sequencing (NGS) are currently the preferred techniques for preimplantation genetic testing for aneuploidies (PGT-A).
Mina Popovic +2 more
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Autism risk in offspring can be assessed through quantification of male sperm mosaicism
Nature Medicine, 2019 De novo mutations arising on the paternal chromosome make the largest known contribution to autism risk, and correlate with paternal age at the time of conception. The recurrence risk for autism spectrum disorders is substantial, leading many families to
Danny Antaki +2 more
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Clonal Hematopoiesis, Somatic Mosaicism, and Age-Associated Disease.
Physiological Reviews, 2022Somatic mosaicism - the occurrence of multiple genetically distinct cell clones within the same tissue - is an evitable consequence of human aging. The hematopoietic system is no exception to this, where studies have revealed the presence of expanded ...
M. A. Evans, K. Walsh
semanticscholar +1 more source