Results 51 to 60 of about 108,116 (254)

RNF138‐Mediated Ubiquitination and Degradation of NS5 Restricts Tick‐Borne Encephalitis Virus Infection

Advanced Science, EarlyView.
Host‐specific compatibility between RNF138‐like proteins and flavivirus NS5 determines NS5 stability. Mammalian RNF138 but not arthropod homologs recognizes and induces conserved NS5/RdRp K48‐linked ubiquitination and proteasomal degradation, thereby restricting viral replication. Ectopic RNF138 in mice attenuates TBEV‐induced pathogenesis. (Created in
Jialiang Sun, Weijing Yang, Hao Zhou, Shuai Li, Xin Jiang, Jianyang Gu, Wenyan Zhang   +6 more
wiley   +1 more source

Fighting Arbovirus Transmission: Natural and Engineered Control of Vector Competence in Aedes Mosquitoes

Insects, 2015
Control of aedine mosquito vectors, either by mosquito population reduction or replacement with refractory mosquitoes, may play an essential role in the fight against arboviral diseases. In this review, we will focus on the development and application of
Joy Kean, Stephanie M. Rainey, Melanie McFarlane, Claire L. Donald, Esther Schnettler, Alain Kohl, Emilie Pondeville   +6 more
doaj   +1 more source

Zebrafish and CRISPR—A synergistic approach to decipher and cure human diseases

Animal Models and Experimental Medicine, EarlyView.
Zebrafish, with high genetic homology to humans, serves as a powerful vertebrate model for disease modeling and drug discovery. Integration of CRISPR/Cas9 technology enables precise genome editing, facilitating the development of translational models for human diseases.
Manikandan Sivaprakasam, Aashika Raagavi Jeanpierre, Salma Mohammed, Rajesh Srinivasan, Aman Kumar Mohanty   +4 more
wiley   +1 more source

Deciphering the Virome of Culex vishnui Subgroup Mosquitoes, the Major Vectors of Japanese Encephalitis, in Japan

Viruses, 2020
Japanese encephalitis (JE) remains a public health concern in several countries, and the Culex mosquito plays a central role in its transmission cycle.
Astri Nur Faizah, Daisuke Kobayashi, Haruhiko Isawa, Michael Amoa-Bosompem, Katsunori Murota, Yukiko Higa, Kyoko Futami, Satoshi Shimada, Kyeong Soon Kim, Kentaro Itokawa, Mamoru Watanabe, Yoshio Tsuda, Noboru Minakawa, Kozue Miura, Kazuhiro Hirayama, Kyoko Sawabe   +15 more
doaj   +1 more source

Lipid Interactions Between Flaviviruses and Mosquito Vectors

Frontiers in Physiology, 2021
Mosquito-borne flaviviruses, such as dengue (DENV), Zika (ZIKV), yellow fever (YFV), West Nile (WNV), and Japanese encephalitis (JEV) viruses, threaten a large part of the human populations.
Thomas Vial, Thomas Vial, Guillaume Marti, Guillaume Marti, Dorothée Missé, Julien Pompon   +5 more
doaj   +1 more source

Duck Orbivirus and Egg Production: A Newly Identified Duck Orbivirus Is the Etiological Agent of Egg Production Decline in Chinese Breeder Ducks

Animal Research and One Health, EarlyView.
Field samples from breeder duck farms with egg‐production decline were subjected to viral detection, genome sequencing, and virus isolation. Experimental infection demonstrated that duck orbivirus (DORV) causes a significant and persistent reduction in egg production in breeder ducks.
Bing Li, Jianhua Wang, Xuezhi Cui, Xinxing Chu, You Wang, Dongmin Hao, Mingqing Xu, Haixia Chang, Huihui Li, Mingtian Mao, Mian Wu, Chengguang Lu, Jing Tang, Suyun Liang, Zhanbao Guo, Zhengkui Zhou, Youxiang Diao, Shuisheng Hou, Yi Tang   +18 more
wiley   +1 more source

Asaia Activates Immune Genes in Mosquito Eliciting an Anti-Plasmodium Response: Implications in Malaria Control

Frontiers in Genetics, 2019
In mosquitoes, the discovery of the numerous interactions between components of the microbiota and the host immune response opens up the attractive possibility of the development of novel control strategies against mosquito borne diseases.
Alessia Cappelli, Claudia Damiani, Maria Vittoria Mancini, Matteo Valzano, Paolo Rossi, Aurelio Serrao, Irene Ricci, Guido Favia   +7 more
doaj   +1 more source

Host, vector, and parasite dynamics: exploring intrinsic and extrinsic factors shaping tick‐borne filarial nematode transmission

Biological Reviews, EarlyView.
ABSTRACT Tick‐borne filarial nematodes are a complex and understudied group of parasites that rely on ticks for transmission in vertebrates. This review examines how intrinsic and extrinsic factors may influence the successful transmission of filarial nematodes in tick vectors, drawing insights from extensively studied haematophagous dipteran vector ...
Oluwaseun D. Ajileye, Gabriel L. Hamer, Sarah A. Hamer, Guilherme G. Verocai, Jessica E. Light   +4 more
wiley   +1 more source

AI-driven convolutional neural networks for accurate identification of yellow fever vectors

Parasites & Vectors
Background Identifying mosquito vectors is crucial for controlling diseases. Automated identification studies using the convolutional neural network (CNN) have been conducted for some urban mosquito vectors but not yet for sylvatic mosquito vectors that ...
Taís Oliveira de Araújo, Vinicius Lima de Miranda, Rodrigo Gurgel-Gonçalves   +2 more
doaj   +1 more source

Flight of the dragons: a global review of migration in Odonata

Biological Reviews, EarlyView.
ABSTRACT Insects are the most abundant and ecologically important animal migrants. Yet, we know relatively little about the patterns and processes underlying insect migration. Dragonflies (Anisoptera) and damselflies (Zygoptera) comprise the ancient insect order Odonata, whose ancestors were the first organisms to fly on Earth.
Johanna S.U. Hedlund, Myles Menz, Jason W. Chapman, Alexander Hayward   +3 more
wiley   +1 more source