Results 51 to 60 of about 57,943 (264)

Repurposing Drugs for Malaria through a Human Dose Prediction: A Case Study with Berzosertib

Clinical Pharmacology &Therapeutics, EarlyView.
Repurposing drugs whose clinical safety has been established offers a valuable approach to reduce the cost and time associated with the development of new drugs for malaria. Here, we investigate the potential to repurpose the anticancer kinase inhibitor berzosertib for the treatment of malaria, by assessing whether a predicted efficacious human dose ...
Devasha Redhi, Mwila Mulubwa, Mmakwena M. Mmonwa, Mathew Njoroge, Liezl Krugmann, Kelly Chibale   +5 more
wiley   +1 more source

LEISHMANIA AND MOSQUITOES. [PDF]

The Lancet, 1911
n ...
openaire   +2 more sources

Viral Dynamic Model‐Informed Dose Selection of Mosnodenvir Prophylaxis against DENV‐3 in a Controlled Human Infection Model

Clinical Pharmacology &Therapeutics, EarlyView.
Dengue virus (DENV) infection is a significant global health threat. Mosnodenvir (JNJ‐64281802) is a pan‐serotype small molecule antiviral blocking DENV replication. A Phase IIa study (NCT05048875) evaluated the antiviral activity, safety, and pharmacokinetics of mosnodenvir as prophylaxis against DENV‐3 in a controlled human infection model (CHIM).
Nele Goeyvaerts, Xavier Woot de Trixhe, Martine Neyens, Thomas N. Kakuda, Liesbeth Van Wesenbeeck, Annemie Buelens, Freya Rasschaert, Anna Durbin, Oliver Ackaert   +8 more
wiley   +1 more source

Drosophila male genitalia rotation depends on permissive remodeling of the posterior abdomen

Developmental Dynamics, EarlyView.
Abstract Background One of the most characteristic morphogenetic processes in Drosophila is the 360° rotation of the male pupal genital disc. This movement is driven by the myosin Myo1D, whose expression in the genital disc is controlled by the Hox gene Abdominal‐B (Abd‐B).
Nuria Prieto, David Foronda, Paloma Martín, Eléanor Simon, Marcus Bischoff, Stéphane Noselli, Ernesto Sánchez‐Herrero   +6 more
wiley   +1 more source

Species composition and fauna distribution of mosquitoes (Diptera: Culicidae) and its importance for vector-borne diseases in a rural area of Central Western - Mato Grosso, Brazil

EntomoBrasilis, 2017
. This study describes ecological data obtained in a rural area in the State of Mato Grosso, including the insects belonging to the family Culicidae, especially those framed as potential vectors of tropical diseases.
Fábio Alexandre Leal-Santos, Adaiane Catarina Marcondes Jacobina, Maria Madalena de Oliveira, Marinalva Brasilina Arruda Santana, Otacília Pereira Serra, Aldimara Vaillant Gonçalves, Angela Regina Serafine Garcêz, Sirlei Franck Thies, Renata Dezengrine Slhessarenko, Elisangela Santana de Oliveira Dantas, Diniz Pereira Leite-Jr   +10 more
doaj   +1 more source

Continental scale metagenomics reveals Microcystis‐induced synchrony among aquatic taxa is exacerbated by trophic cascades

Ecography, EarlyView.
Harmful Microcystis proliferation severely threatens aquatic ecosystems globally, but its impacts on food‐web stability remain poorly understood. Here, we analyzed 1309 metagenomic samples from freshwater ecosystems across China to investigate how Microcystis abundance affects synchrony among taxa in multi‐trophic food webs (from bacteriophages to ...
Lemian Liu, Siqi Zhu, Xiaoqin Huang, Wenjia Hu, Lixiang Luo, Xiusong Pan, Jianfeng Chen   +6 more
wiley   +1 more source

Bionomics and malaria infection rates in anopheline species in Yanomami villages of the Brazilian Amazon Forest

Malaria Journal
Background Malaria remains a major public health challenge in Brazil, particularly in the Amazon region, where over 90% of cases occur. Indigenous populations, such as the Yanomami, are disproportionately affected due to geographic isolation and ...
Jordi Sánchez-Ribas, Teresa Fernandes Silva-do-Nascimento, Cleomar Pereira-Ribeiro, Maycon Sebastião Alberto Santos-Neves, John W. Barnwell, Ricardo Lourenço-de-Oliveira, Joseli Oliveira-Ferreira   +6 more
doaj   +1 more source

MOSQUITO BITES. [PDF]

The Lancet, 1881
n ...
openaire   +1 more source

Research progress on flexible MXene‐based materials in advanced energy storage devices: From preparation strategies to device applications

FlexMat, EarlyView.
This review summarizes MXene synthesis and flexible electrode fabrication for FESDs, highlighting their potential owing to high conductivity and flexibility, and outlines future research directions. Abstract The rapid development of wearable and portable electronics has created demand for flexible energy storage systems (FESDs) that not only exhibit ...
Nanxi Miao, Ying Lu, Xing Gao, Lingzi Pan, Meng Gao, Chenxi Zhang, Ming Liu, Shizhong Wang, Zhongyu Weng, Huan Pang, Huijie Zhou   +10 more
wiley   +1 more source

Oropouche orthobunyavirus in Urban Mosquitoes: Vector Competence, Coinfection, and Immune System Activation in Aedes aegypti

Viruses
Oropouche orthobunyavirus (OROV) is an emerging public health concern due to its expanding geographic range and increasing case numbers. In Brazil, 13,785 cases were confirmed in 2024, with an additional 3680 reported by January 2025, according to the ...
Silvana F. de Mendonça, Lívia V. R. Baldon, Yaovi M. H. Todjro, Bruno A. Marçal, Maria E. C. Rodrigues, Rafaela L. Moreira, Ellen C. Santos, Marcele N. Rocha, Isaque J. da S. de Faria, Bianca D. M. Silva, Thiago N. Pereira, Amanda C. de Freitas, Myrian M. Duarte, Felipe C. de M. Iani, Natália R. Guimarães, Talita E. R. Adelino, Marta Giovanetti, Luiz C. J. Alcantara, Álvaro G. A. Ferreira, Luciano A. Moreira   +19 more
doaj   +1 more source