Results 41 to 50 of about 3,140,400 (284)

In vitro models of cancer‐associated fibroblast heterogeneity uncover subtype‐specific effects of CRISPR perturbations

open access: yesMolecular Oncology, EarlyView.
Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra   +10 more
wiley   +1 more source

My Ecuadorian Host Mother [PDF]

open access: yes, 2018
While still in the midst of their study abroad experiences, students at Linfield College write reflective essays. Their essays address issues of cultural similarity and difference, compare lifestyles, mores, norms, and habits between their host countries
Bissey, Nicole
core   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

open access: yesFEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada   +5 more
wiley   +1 more source

Impaired voice processing in reward and salience circuits predicts social communication in children with autism

open access: yeseLife, 2019
Engaging with vocal sounds is critical for children’s social-emotional learning, and children with autism spectrum disorder (ASD) often ‘tune out’ voices in their environment.
Daniel Arthur Abrams   +7 more
doaj   +1 more source

Alien and Degenerate Milk: Embodiment, Mapping, and Social Identity in Four Nursing Metaphors

open access: yesJournal for Interdisciplinary Biblical Studies, 2022
Using cognitive metaphor theory to examine the four NT nursing metaphors (1 Thess 2:5–9; 1 Cor 3:1–3; Heb 5:11–14; 1 Pet 2:1–3), this article demonstrates that the same nursing frame can be used quite differently. The work of separating the contributions
Laura J. Hunt
doaj   +1 more source

The World War II Patriotic Mother [PDF]

open access: yes, 2010
The archetypal good mother and the archetypal patriotic mother are important symbols in American culture. Both are rooted in maternal work but are separated by two conflicting assumptions. The good mother nurtures her children and protects them from harm,
Garner, Ana C., Slattery, Karen L.
core   +1 more source

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

open access: yesFEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida   +6 more
wiley   +1 more source

The Language Maintenance of Mother Tongue in Tourism Area, Ubud [PDF]

open access: yes, 2016
This study entitled "The Language Maintenance of Mother Tongue in Tourism Area, Ubud". The background of this study is departed from having seen the phenomenon of a rapid tourism development in Ubud. The arrival of tourists, both domestics and foreigners,
Maharani, S. A. (Sang)
core  

Effect of maternal panic disorder on mother-child interaction and relation to child anxiety and child self-efficacy [PDF]

open access: yes, 2009
To determine whether mothers with panic disorder with or without agoraphobia interacted differently with their children than normal control mothers, 86 mothers and their adolescents (aged between 13 and 23 years) were observed during a structured play ...
A Goldstein   +43 more
core   +1 more source

Exploratory Analysis of ELP1 Expression in Whole Blood From Patients With Familial Dysautonomia

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Familial dysautonomia (FD) is a hereditary neurodevelopmental disorder caused by aberrant splicing of the ELP1 gene, leading to a tissue‐specific reduction in ELP1 protein expression. Preclinical models indicate that increasing ELP1 levels can mitigate disease manifestations.
Alejandra González‐Duarte   +13 more
wiley   +1 more source

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