Results 131 to 140 of about 244,158 (323)

Engineered Microfluidic Organoid Systems: New Paradigms for Menopause Mechanism Research and Personalized Medicine

open access: yesAdvanced Materials Technologies, EarlyView.
This review explores the integration of microfluidic technology with organoid systems as an innovative platform for studying menopausea complex multi‐organ condition. By enabling precise simulation of inter‐organ communication and hormone responses, microfluidic organoids offer a physiologically relevant model for investigating menopausal syndrome and ...
Qianyi Zhang   +4 more
wiley   +1 more source

The Changing Pathways of Hispanic Youths Into Adulthood [PDF]

open access: yes, 2009
Analyzes 1970-2007 census data for trends in skills acquisition, school enrollment, labor force participation, military enlistment, marriage and parenting, and incarceration among Latino youths.
Richard Fry
core  

Predicting Macrophage Spatial Localization from Single‐Cell Transcriptomes to Uncover Disease Mechanisms

open access: yesAdvanced Science, EarlyView.
This study presents a machine‐learning framework entitled MERLIN that infers the microanatomical localization of macrophages from single‐cell transcriptomic data in structured organs such as the kidney and brain. Applying this method to existing datasets from models of acute kidney injury and diabetic nephropathy uncovered spatially resolved insights ...
Junping Yin   +18 more
wiley   +1 more source

The motherhood penalty in the United Kingdom: An unconditional quantile regression analysis

open access: yesInternational Labour Review
Utilizing data from the UK Household Longitudinal Study, we employ panel methodologies and unconditional quantile regression (UQR) analysis to explore the prevalence and impact of the motherhood penalty within the context of the United Kingdom. Our panel
doaj   +2 more sources

“Motherhood forced me to cope with my disability”: identity intersection among mothers with physical disabilities

open access: yesFrontiers in Psychology
BackgroundAlthough motherhood plays a meaningful role in the formation of a woman’s identity, most studies have focused on the process of identity transformation in the transition to motherhood among non-disabled women; less is known about this process ...
Carmit-Noa Shpigelman   +2 more
doaj   +1 more source

Indole‐3‐Propionic Acid Improves Alveolar Development Impairment via Targeting VAMP8‐mediated SNAREs Complex Formation in Bronchopulmonary Dysplasia

open access: yesAdvanced Science, EarlyView.
This study aims to evaluate the impact of the tryptophan‐derived metabolite indole‐3‐propionic acid (IPA) on lung development and autophagic flux. IPA alleviates hyperoxia‐induced alveolar arrest by promoting autophagosome‐lysosome fusion via inhibition of VAMP8 phosphorylation, which is suggestive of a promising therapeutic target of BPD.
Beibei Wang   +14 more
wiley   +1 more source

Dynamics of the Mammalian Placental Metabolome in Placentogenesis and Embryonic Development

open access: yesAdvanced Science, EarlyView.
This study identifies three metabolic stages (E8.5, E9.5–10.5, E11.5–14.5) and two transition periods (E8.5–9.5, E10.5–11.5) in mouse placental development. NAD(H) emerges as a key dynamic metabolite that enhances embryonic growth through accelerated segmentation and increased proliferation of mouse embryonic stem cell (mESC)‐induced presomitic ...
Gang Chen   +11 more
wiley   +1 more source

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