Results 41 to 50 of about 1,723,878 (343)

The Co-occurrence of child and intimate partner maltreatment in the family: characteristics of the violent perpetrators [PDF]

, 2007
This study considers the characteristics associated with mothers and fathers who maltreat their child and each other in comparison to parents who only maltreat their child.
A. E. Appel, A. Holtzworth-Munroe, American Psychiatric Association, C. Coohey, C. E. Cox, C. Goddard, C. Hartley, C. Renzetti, Catherine Hamilton-Giachritsis, D. G. Saunders, D. G. Saunders, D. S. Riggs, E. A. Tajima, E. Farmer, Eugene Ostapuik, J. Archer, J. Archer, J. D. Osofsky, J. L. Crouch, J. L. Edleson, K. Browne, K. D. Browne, K. D. Browne, K. D. Browne, K. D. Browne, K. D. Browne, K. D. Browne, K. Herron, Kevin Browne, L. A. McCloskey, L. Dixon, L. Dixon, L. Falshaw, Louise Dixon, M. A. Cerezo, M. A. Straus, M. A. Straus, M. A. Straus, M. Hester, M. O’Keefe, M. P. Johnson, N. J. Morton, P. D. Rumm, R. P. Dobash, R. R. Abidin, S. K. Beeman, S. M. Ross, S. Salzinger, T. J. Dishion, T. Millon   +49 more
core   +2 more sources

The anabolic steroid stanozolol is a potent inhibitor of human MutT homolog 1

FEBS Letters, EarlyView.
MutT homolog 1 (MTH1) is a member of the NUDIX superfamily of enzymes and is an anticancer drug target. We show that stanozolol (Stz), an anabolic steroid, is an unexpected nanomolar inhibitor of MTH1. The X‐ray crystal structure of the human MTH1–Stz complex reveals a unique binding scaffold that could be utilized for future inhibitor development ...
Emma Scaletti Hutchinson, Robert Gustafsson Westergren, Ingrid Almlöf, Ann‐Sofie Jemth, Martin Scobie, Ulrika Warpman Berglund, Thomas Helleday, Pål Stenmark   +7 more
wiley   +1 more source

Complex cytogenetic abnormalities in chronic myeloid leukemia resulting in early progression to blast crisis: a case report

Journal of Medical Case Reports, 2020
Introduction BCR-ABL1, resulting from t(9;22), is the oncogenic driver of chronic myeloid leukemia and the therapeutic target of the disease. Molecular studies have been the gold standard modality for patient assessment since the advent of tyrosine ...
Haider Ali Malakzai, Soma Rahmani, Ahmed Maseh Haidary, Sarah Noor, Maryam Ahmad, Abdul Sami Ibrahimkhil, Samuel Sharif   +6 more
doaj   +1 more source

Ergothioneine supplementation improves pup phenotype and survival in a murine model of spinal muscular atrophy

FEBS Letters, EarlyView.
Spinal muscular atrophy (SMA) is a genetic disease affecting motor neurons. Individuals with SMA experience mitochondrial dysfunction and oxidative stress. The aim of the study was to investigate the effect of an antioxidant and neuroprotective substance, ergothioneine (ERGO), on an SMNΔ7 mouse model of SMA.
Francesca Cadile, Daniela Ratto, Giorgia Rastelli, Ottavia Eleonora Ferraro, Caterina Temporini, Sunil Kumar, Simona Boncompagni, Paola Rossi, Monica Canepari   +8 more
wiley   +1 more source

Aberrant expression of nuclear prothymosin α contributes to epithelial‐mesenchymal transition in lung cancer

Molecular Oncology, EarlyView.
Nuclear prothymosin α inhibits epithelial‐mesenchymal transition (EMT) in lung cancer by increasing Smad7 acetylation and competing with Smad2 for binding to SNAI1, TWIST1, and ZEB1 promoters. In early‐stage cancer, ProT suppresses TGF‐β‐induced EMT, while its loss in the nucleus in late‐stage cancer leads to enhanced EMT and poor prognosis.
Liyun Chen, Chung‐Teng Wang, Jia‐Ming Chang, Ai‐Li Shiau, Gia‐Shing Shieh, Yau‐Lin Tseng, Yi‐Ting Yen, Tang‐Hsiu Huang, Li‐Hsin Cheng, Yu‐Chih Wu, Chao‐Liang Wu, Bing‐Hua Su, Pensee Wu   +12 more
wiley   +1 more source

Mometasone Furoate–Induced Iatrogenic Cushing’s Syndrome and Secondary Adrenal Insufficiency: A Case Report

Case Reports in Pediatrics
Intranasal corticosteroids (INCS) are widely used to treat allergic rhinitis and nasal obstruction. While their safety profile is generally well established, both local and systemic side effects can occur.
Anna Insalaco, Sara Vandelli, Simona F. Madeo, Patrizia Bruzzi, Viola Trevisani, Barbara Predieri, Laura Lucaccioni, Lorenzo Iughetti   +7 more
doaj   +1 more source

Somatisation and functional impairment in adolescents: longitudinal link with mothers' reactions [PDF]

, 2014
Adolescents' somatisation (i.e., the psychological tendency to experience and report multiple physical complaints for which no definite medical cause can be found; SOM) and functional impairment (i.e., all bothersome aftermath of somatisation; FI) were ...
Desoete, Annemie, Grietens, H, Hoppenbrouwers, K, Rousseau, S, Van Leeuwen, K, Vanderfaeillie, J   +5 more
core   +3 more sources

Systematic profiling of cancer‐fibroblast interactions reveals drug combinations in ovarian cancer

Molecular Oncology, EarlyView.
Fibroblasts, cells in the tumor environment, support ovarian cancer cell growth and alter morphology and drug response. We used fibroblast and cancer cell co‐culture models to test 528 drugs and discovered new drugs for combination treatment. We showed that adding Vorinostat or Birinapant to standard chemotherapy may improve drug response, suggesting ...
Greta Gudoityte, Osheen Sharma, Laura Leuenberger, Emelie Wallin, Josefin Fernebro, Päivi Östling, Rebecka Bergström, Johan Lindberg, Ulrika Joneborg, Olli Kallioniemi, Brinton Seashore‐Ludlow   +10 more
wiley   +1 more source

Young mothers in care, contributing to the contemporary debate [PDF]

, 2008
Teenage pregnancy has become a broad issue in contemporary society and has become a focus for concern for young women in or exiting the care system. The article draws on interviews with twenty-four young mothers in, or on the fringes of the care system ...
Aldgate J., Allen I., Bowlby J., Corlyon J., Hadley A., Hudson F., Jane Reeves, Moms J., Phoenix A., Tabberer S., Triseliotis J.   +10 more
core   +1 more source

Mothers 2 Mothers

South African Journal of Obstetrics and Gynaecology, 2006
No Abstract.South African Journal of Obstetrics and Gynaecology Vol. 12 (3) 2006: pp.
openaire   +3 more sources