Results 121 to 130 of about 804,099 (314)

INTER ET INTRA TEXTE DANS NUIT RHÉNANE D’APOLLINAIRE [PDF]

open access: yesStudii si Cercetari Filologice: Seria Limbi Romanice, 2010
Le poème Nuit rhénane est illustratif pour l’inspiration allemande du poète, qui construit son texte en se servant des légendes germaniques, sans se rapporter précisément à aucune d’entre elles ; il en recrée le cadre fantastique et en emprunte les ...
Alexandrina MUSTATEA
doaj  

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Structure of the story in Qasas ul-Anbiya of Kisa'i (Stories of the Prophets) [PDF]

open access: yesMatn/Pizhūhī-i Adabī, 2015
Qasas Ul Anbiya by Kisa'i is a works in Arabic by Muhammad b. Abdullah al-Kisa'i. The realidentityof itsauthoris not well known. This work is common in Islamiccommunities, especially among the public withnames such as“Bad’aldonya VA Qisas ul-Anbiya ...
Kazem Dezfolian, Gholamreza Rafiei
doaj  

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

open access: yesMolecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Interpreting the effects of DNA polymerase variants at the structural level

open access: yesMolecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi   +7 more
wiley   +1 more source

ZONGULDAK MADENCİLİK MESLEĞİ GELENEĞİNE BAĞLI OLUŞAN MEMORATLAR ÜZERİNE BİR DEĞERLENDİRME

open access: yes, 2019
Folklor, ozellikle de meslek folkloru baglaminda ele alindiginda, her meslegin kendine ozgu kurallarinin yani sira anlatilarinin, jargonunun, inanis ve uygulamalarinin oldugu gorulur. Baska bir deyisle, bireyle meslek arasindaki iliski sadece maddi degil,
Berna Ayaz, Aykut Günaydin
core   +1 more source

Kahramanmaras Çeyiz Sandığı Oyma Motiflerinin Đncelenmesi

open access: yesDüzce University Faculty of Forestry Journal of Forestry, 2008
Bu çalısmayla gün geçtikçe kaybolan oymacılığın ve çeyiz sandığı oymamotiflerinin muhafaza edilerek, gelecek nesillere aktarılması amaçlanmıstır. Çeyizsandığı oymacılığı Türkiye’de en yaygın olarak Kahramanmaras ilinde yapılmaktadır.Bu arastırmada ...
Murat Özalp, Derya Sevim Korkut
doaj  

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

open access: yesMolecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober   +16 more
wiley   +1 more source

KONYA MERAM İLÇESİKARADİĞİN KASABASI’NDA KANAVİÇE İŞLEMELER

open access: yesSelçuk Üniversitesi Sosyal Bilimler Enstitüsü Dergisi, 2004
Anadolu’nun çeşitli yörelerinde tekniği aynı, fakat, motif, renk ve kompozisyon farklılıklarıile karşımıza çıkan kanaviçe işlemelerine; Konya Meram İlçesi Karadiğin Kasabası’nda rastlanmıştır.
Gülizar Altun
doaj  

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

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