Results 31 to 40 of about 652,018 (265)
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
Modelling stem cell differentiation related processes—A practical overview for biologists
FEBS Letters, EarlyView.Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar +4 more
wiley +1 more source
Nucleic Acids Research, 2014 The Motif Enrichment Tool (MET) provides an online interface that enables users to find major transcriptional regulators of their gene sets of interest. MET searches the appropriate regulatory region around each gene and identifies which transcription factor DNA-binding specificities (motifs) are statistically overrepresented. Motif enrichment analysis
Charles Blatti, Saurabh Sinha 0002
openaire +3 more sources
International Journal for Innovation Education and Research, 2022 The popularization of online video platforms has also increased the number of producers who, with reduced teams or composed of a single person, have an inexperienced profile in this activity. Thus, among the various specificities of the material produced, the sound issue tends to be underestimated, sometimes harming the message to be transmitted.
Luiz Guilherme Marques +1 more
openaire +2 more sources
The image of the Russian North in the novel by Mikhail Tarkovsky “Toyota cross” [PDF]
Актуальные проблемы филологии и педагогической лингвистики, 2019 In this article the author describes the concept of the Northern text on the example of M. Tarkovsky’s novel “Toyota cross”. The Northern text is understood in a broad sense, which includes the spaces of Krasnoyarsk, the Far East, Siberia, etc..
Sazonova Anastasia S.
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
The annotation of RNA motifs [PDF]
Comparative and Functional Genomics, 2002 AbstractThe recent deluge of new RNA structures, including complete atomic‐resolution views of both subunits of the ribosome, has on the one hand literally overwhelmed our individual abilities to comprehend the diversity of RNA structure, and on the other hand presented us with new opportunities for comprehensive use of RNA sequences for comparative ...
Leontis, Neocles B., Westhof, Eric
openaire +3 more sources
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Motifs and Motif Generalization in Chinese Word Networks
Procedia Computer Science, 2012 AbstractThe most significant semantic unit of Chinese language is words composed of individual characters. This com–positional structure produces great variability and representability compared to individual characters, which is quite distinct from other languages.
Jianyu Li +3 more
openaire +2 more sources
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source