Results 51 to 60 of about 1,451,444 (296)

Two Faces of NOTCH1 in Childhood Lymphoblastic T‐Cell Neoplasia: Prognostic Divergence of Mutational and Structural Aberrations

open access: yesPediatric Blood &Cancer, EarlyView.
ABSTRACT In pediatric patients, T‐cell lymphoblastic lymphoma (T‐LBL) survival exceeds 80%. Relapse remains associated with limited curative options. Frontline treatment is largely extrapolated from T‐cell acute lymphoblastic leukemia (T‐ALL) treatment, reflecting the ongoing debate, whether both entities represent distinct diseases or variants within ...
Marie C. Heider   +4 more
wiley   +1 more source

The motif problem [PDF]

open access: yes, 2012
Fix a choice and ordering of four pairwise non-adjacent vertices of a parallelepiped, and call a motif a sequence of four points in R^3 that coincide with these vertices for some, possibly degenerate, parallelepiped whose edges are parallel to the axes ...
Canfield, E. Rodney   +3 more
core  

Data mining of protein families using common peptides [PDF]

open access: yes, 2008
Predicting the function of a protein from its sequence is typically addressed using sequence-similarity. Here we propose a motif-based approach, using supervised motif extraction from protein sequences belonging to one functional family.
Assaf Gottlieb, David Horn, Uri Weingart
core   +3 more sources

Mapping the evolution of mitochondrial complex I through structural variation

open access: yesFEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin   +2 more
wiley   +1 more source

The image of the Russian North in the novel by Mikhail Tarkovsky “Toyota cross” [PDF]

open access: yesАктуальные проблемы филологии и педагогической лингвистики, 2019
In this article the author describes the concept of the Northern text on the example of M. Tarkovsky’s novel “Toyota cross”. The Northern text is understood in a broad sense, which includes the spaces of Krasnoyarsk, the Far East, Siberia, etc..
Sazonova Anastasia S.
doaj   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

open access: yesFEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Modelling the evolution of transcription factor binding preferences in complex eukaryotes [PDF]

open access: yes, 2017
Transcription factors (TFs) exert their regulatory action by binding to DNA with specific sequence preferences. However, different TFs can partially share their binding sequences due to their common evolutionary origin.
Caselle, Michele   +3 more
core   +2 more sources

Motifs and Motif Generalization in Chinese Word Networks

open access: yesProcedia Computer Science, 2012
AbstractThe most significant semantic unit of Chinese language is words composed of individual characters. This com–positional structure produces great variability and representability compared to individual characters, which is quite distinct from other languages.
Jianyu Li   +3 more
openaire   +1 more source

The motif tracking algorithm [PDF]

open access: yesInternational Journal of Automation and Computing, 2008
The search for patterns or motifs in data represents a problem area of key interest to finance and economic researchers. In this paper we introduce the Motif Tracking Algorithm, a novel immune inspired pattern identification tool that is able to identify unknown motifs of a non specified length which repeat within time series data.
William O. Wilson   +2 more
openaire   +5 more sources

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

open access: yesFEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho   +3 more
wiley   +1 more source

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