Results 61 to 70 of about 804,099 (314)
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Kajian estetika pada motif batik Sekar Jagad Yogyakarta
Jurnal DesainTujuan penelitian untuk mengkaji nilai estetika yang terdapat pada motif batik sekar jagad yang memiliki banyak ragam hias pada kainnya. Ragam hias di Yogyakarta dan Surakarta mengandung filosofi di dalamnya seperti keberuntungan, kekayaan, kebaikan ...
Ferdy Ferdiaz +2 more
doaj +1 more source
Motif-Aware PRALINE: Improving the alignment of motif regions
PLOS Computational Biology, 2018 Protein or DNA motifs are sequence regions which possess biological importance. These regions are often highly conserved among homologous sequences. The generation of multiple sequence alignments (MSAs) with a correct alignment of the conserved sequence motifs is still difficult to achieve, due to the fact that the contribution of these typically short
Maurits J. J. Dijkstra +5 more
openaire +4 more sources
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Motif-fingerprints of the networks by time—Grouped by type.
, 2018 Motif-fingerprints of the networks by time—Grouped by type.
Pedro Ribeiro (358683) +2 more
core +1 more source
FEBS Letters, EarlyView.This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley +1 more source
Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations
FEBS Letters, EarlyView.The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas +6 more
wiley +1 more source
“KÖTÜ KEDİ ŞERAFETTİN” ANİMASYON FİLMİNİN TOPLUMSAL CİNSİYET BAĞLAMINDA ÇÖZÜMLENMESİ
, 2021 Toplum içinde bireylerin biyolojik cinsiyetleri sosyal yaşamla beraber değişimeuğramaktadır. Bu değişimler bireyin toplumdaki rollerini ve bakış açılarınısınırlandırmaktadır.
Rugeş DEMİR, DEMİR, Rugeş
core +1 more source
Nucleic Acids Research, 2014 The Motif Enrichment Tool (MET) provides an online interface that enables users to find major transcriptional regulators of their gene sets of interest. MET searches the appropriate regulatory region around each gene and identifies which transcription factor DNA-binding specificities (motifs) are statistically overrepresented. Motif enrichment analysis
Charles Blatti, Saurabh Sinha 0002
openaire +2 more sources
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source