Results 61 to 70 of about 632,779 (266)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

“Floral Ornament of Reality”: Flowers in Worldview of E. T. A. Hoffmann and N. A. Polevoy

Научный диалог
The relevance of this study is grounded in the scholarly significance of the issue of Russian-German literary connections as a crucial factor in intercultural interaction.
N. M. Ilchenko, E. G. Chernysheva
doaj   +1 more source

Evolutionary Analyses Reveal Diverged Patterns of SQUAMOSA Promoter Binding Protein-Like (SPL) Gene Family in Oryza Genus

Frontiers in Plant Science, 2019
The SPL (SQUAMOSA promoter binding protein-like) gene family is one of the plant-specific transcription factor families and controls a considerable number of biological functions, including floral development, phytohormone signaling, and toxin resistance.
Hua Zhong, Weilong Kong, Ziyun Gong, Xinyi Fang, Xiaoxiao Deng, Chang Liu, Yangsheng Li   +6 more
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Bir Taşra Camii Olarak Kozluca Camii’nin Kalem İşi Süslemeler Bağlamında Değerlendirmesi

İlahiyat Akademi
Gaziantep’in Şahinbey ilçesinde yer alan Kozluca Camii, Osmanlı sanatında, özellikle de süsleme alanında batılı etkilerin Anadolu’daki taşra camilerine nasıl yansıdığını göstermesi açısından büyük önem taşımaktadır.
Fevziye Eker, Furkan Köksöken
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

Kirkitli Dokuma Örnekleri İle Selçuklu Dönemi Mimari Yapılarında Kullanılan Ortak Motifler Üzerine Bir İnceleme ‘‘Aksaray Sultanhanı, Ağzıkarahan ve Alayhan Hanları’’

Sanat ve İkonografi Dergisi
Türklerin yerleşik hayata geçmesi ile birlikte barınma yerlerini inşasında ilk olarak toprak kullanmışlar ve daha sonra Selçuklular dönemi ile tuğla ve taş kullanmaya başlamışlardır.
Ahmet Melih Çilingir, Semra Kılıç Karatay   +1 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

„Kõik on muidugi selle poolt.” Koosoleku motiiv sotsialistliku korra retrospektiivsel kujutamisel

Keel ja Kirjandus
”Everybody’s in favour, of course.” Meetings as a motif in retrospective depictions of the socialist order This article examines the portrayal of meetings in four novels: Enn Vetemaa’s “The Musician” (Pillimees), Herta Müller’s “The Land of Green ...
Inga Kirs
doaj   +1 more source

Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network

FEBS Letters, EarlyView.
Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley   +1 more source