Results 81 to 90 of about 1,451,444 (296)
From planar surfaces based on lattices to freeform surfaces based on triangular meshes: an advanced extension of the areal motif method [PDF]
, 2015 Surfaces are shifting from traditional planar surfaces to freeform surfaces with significantly reduced volume and weight and highly improved performance.
Abdul-Rahman, Hussein S. +4 more
core
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Chemoenzymatic Probes for Detecting and Imaging Fucose-α(1-2)-galactose Glycan Biomarkers [PDF]
, 2012 The disaccharide motif fucose-α(1-2)-galactose (Fucα(1-2)Gal) is involved in many important physiological processes, such as learning and memory, inflammation, asthma, and tumorigenesis.
Becker D. J. +30 more
core +3 more sources
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Salivary cytokine panel indicative of non-small cell lung cancer. [PDF]
, 2018 Objective To develop a combinatorial panel of salivary cytokines that manifests the presence of non-small cell lung cancer (NSCLC) that will eventually improve prognosis by facilitating the early diagnosis and management of this common cancer. Methods We
Koizumi, Tomonobu +2 more
core +3 more sources
The annotation of RNA motifs [PDF]
Comparative and Functional Genomics, 2002 AbstractThe recent deluge of new RNA structures, including complete atomic‐resolution views of both subunits of the ribosome, has on the one hand literally overwhelmed our individual abilities to comprehend the diversity of RNA structure, and on the other hand presented us with new opportunities for comprehensive use of RNA sequences for comparative ...
Leontis, Neocles B., Westhof, Eric
openaire +3 more sources
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source
Comprehensive Analysis of Breast Cancer Cell Lines: Genome-wide Insights from ChIP-seq Analysis
Biomedical and Biotechnology Research JournalContext: Chromatin immunoprecipitation followed by sequencing (ChIP-seq) is the central system in epigenomic exploration. Chromatin immunoprecipitation coupled with sequencing (ChIP-seq) is an important technology to identify the genome-wide location of ...
Tanishq Sahu, Ruchi Yadav
doaj +1 more source
Motif of "AbuzarGhaffari" in Yahyaal-Samawy’s Poetry [PDF]
پژوهشهای ترجمه در زبان و ادبیات عربی, 2012 As one of the important elements in literary critisism and analysis, motif is taken into consideration in European criticism. Originally as a French word, motif means the main thought or the subject or the iterative words and phrases in literature.
Marzieh Abad, Rasol Ballavi
doaj +1 more source
Cohesin cleavage by separase is enhanced by a substrate motif distinct from the cleavage site. [PDF]
, 2019 Chromosome segregation begins when the cysteine protease, separase, cleaves the Scc1 subunit of cohesin at the metaphase-to-anaphase transition.
Asfaha, Jonathan B +6 more
core +1 more source