Results 91 to 100 of about 1,451,444 (296)

AAA+ protein unfoldases—the Moirai of the proteome

FEBS Letters, EarlyView.
AAA+ unfoldases are essential molecular motors that power protein degradation and disaggregation. This review integrates recent cryo‐electron microscopy (cryo‐EM) structures and single‐molecule biophysical data to reconcile competing models of substrate translocation.
Stavros Azinas, Marta Carroni
wiley   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

“Floral Ornament of Reality”: Flowers in Worldview of E. T. A. Hoffmann and N. A. Polevoy

Научный диалог
The relevance of this study is grounded in the scholarly significance of the issue of Russian-German literary connections as a crucial factor in intercultural interaction.
N. M. Ilchenko, E. G. Chernysheva
doaj   +1 more source

Evolutionary Analyses Reveal Diverged Patterns of SQUAMOSA Promoter Binding Protein-Like (SPL) Gene Family in Oryza Genus

Frontiers in Plant Science, 2019
The SPL (SQUAMOSA promoter binding protein-like) gene family is one of the plant-specific transcription factor families and controls a considerable number of biological functions, including floral development, phytohormone signaling, and toxin resistance.
Hua Zhong, Weilong Kong, Ziyun Gong, Xinyi Fang, Xiaoxiao Deng, Chang Liu, Yangsheng Li   +6 more
doaj   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Motifs

, 2023
This dissertation explores the application of motif discovery in real-world time series, specifically focused on the impact of preprocessing steps on the detection of exact and approximate meaningful motifs (chapters 3 and 4). The results shed light on the discrepancy between commonly held assumptions about normalization and parameter settings and the ...
openaire   +3 more sources

Bir Taşra Camii Olarak Kozluca Camii’nin Kalem İşi Süslemeler Bağlamında Değerlendirmesi

İlahiyat Akademi
Gaziantep’in Şahinbey ilçesinde yer alan Kozluca Camii, Osmanlı sanatında, özellikle de süsleme alanında batılı etkilerin Anadolu’daki taşra camilerine nasıl yansıdığını göstermesi açısından büyük önem taşımaktadır.
Fevziye Eker, Furkan Köksöken
doaj   +1 more source

Microsatellite primers for red drum (Sciaenops ocellatus) [PDF]

, 2008
In this note, we document polymerase-chain-reaction (PCR) primer pairs for 101 nuclear-encoded microsatellites designed and developed from a genomic library for red drum (Sciaenops ocellatus).
Gold, John R., Karlsson, Sten, Renshaw, Mark A., Rexroad III, Caird E.   +3 more
core  

First principles structures and circular dichroism spectra for the close-packed and the 7/2 motif of collagen

, 2012
The recently proposed close-packed motif for collagen is investigated using first principles semi-empirical wave function theory and Kohn-Sham density functional theory. Under these refinements the close-packed motif is shown to be stable.
Bhatnagar R. S., Frisch M. J., Jakob Bohr, Karl J. Jalkanen, Kasper Olsen, Michaela Knapp-Mohammady, Okuyama K., Olsen K.   +7 more
core   +1 more source