Results 51 to 60 of about 420,339 (255)
“Great Sinners” and Righteous People of L. N. Tolstoy and F. M. Dostoevsky in the Light of A. A. Ukhtomsky’s Ethical Teaching [PDF]
Два века русской классикиThe article proposes a typology of righteous heroes on the material of L. N. Tolstoy’s stories “Father Sergius,” “False Coupon,” “Alyosha the Pot,” and F. M.
Elena A. Fedorova
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Multiple ETS family transcription factors bind mutant p53 via distinct interaction regions
FEBS Letters, EarlyView.Mutant p53 gain‐of‐function is thought to be mediated by interaction with other transcription factors. We identify multiple ETS transcription factors that can bind mutant p53 and found that this interaction can be promoted by a PXXPP motif. ETS proteins that strongly bound mutant p53 were upregulated in ovarian cancer compared to ETS proteins that ...
Stephanie A. Metcalf +6 more
wiley +1 more source
PhytoFrontiersPeppers are a crucial source of nutrition and supplement human diets worldwide. They are of vital importance to the agricultural and food industries, especially in developing countries where growers heavily rely on the production and export of pepper. In
Vishwesh Dayal, Caleb Paslay, Akhtar Ali
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Geometry Concept on the Motifs of Woven Fabric in Kefamenanu Community
Journal of Research and Advances in Mathematics Education, 2019 For the Kefamenanu community, the motif serves as the identity of the person who wears it. Nevertheless, the woven fabric must be present at cultural occasions, welcoming guests, and death ceremonies.
Yohanis Ndapa Deda, Stanislaus Amsikan
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FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Immunogenetics, 2008 In vertebrates, the major histocompatibility complex (MHC) presents peptides to the immune system. In humans, MHCs are called human leukocyte antigens (HLAs), and some of the loci encoding them are the most polymorphic in the human genome. Different MHC molecules present different subsets of peptides, and knowledge of their binding specificities is ...
Nicolas, Rapin +3 more
openaire +2 more sources
In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS
FEBS Letters, EarlyView.We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka +11 more
wiley +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
PICALM::MLLT10 translocated leukemia
FEBS Letters, EarlyView.This comprehensive review of PICALM::MLLT10 translocated acute leukemia provides an in‐depth review of the structure and function of CALM, AF10, and the fusion oncoprotein (1). The multifaceted molecular mechanisms of oncogenesis, including nucleocytoplasmic shuttling (2), epigenetic modifications (3), and disruption of endocytosis (4), are then ...
John M. Cullen +7 more
wiley +1 more source
Decoding the Terracotta Tablet Found in Shadyakh Islamic Site of Neishabour [PDF]
نگره, 2015 Symbols have broader functions in the Islamic era in comparison to the pre-Islamic time, the cause of which may be the change of religion and spiritual approach that occurred in the Islamic world.
Abbas Sheikhi, Leila Ghafarpoor
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