Results 61 to 70 of about 577,004 (315)

The annotation of RNA motifs [PDF]

Comparative and Functional Genomics, 2002
AbstractThe recent deluge of new RNA structures, including complete atomic‐resolution views of both subunits of the ribosome, has on the one hand literally overwhelmed our individual abilities to comprehend the diversity of RNA structure, and on the other hand presented us with new opportunities for comprehensive use of RNA sequences for comparative ...
Leontis, Neocles B., Westhof, Eric
openaire   +3 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

On the Discovery of Significant Motifs in Genomic Sequences [PDF]

, 2013
In this thesis we study the statistical properties of some families of motifs of the same length. We develop a method for the approximation of the average number of frequent motifs in the family in random texts with independent characters.
Boscariol, Matteo
core  

Coupling to short linear motifs creates versatile PME-1 activities in PP2A holoenzyme demethylation and inhibition [PDF]

, 2022
Protein phosphatase 2A (PP2A) holoenzymes target broad substrates by recognizing short motifs via regulatory subunits. PP2A methylesterase 1 (PME-1) is a cancer-promoting enzyme and undergoes methylesterase activation upon binding to the PP2A core enzyme.
Li, Yitong, Anastasia Phoebe Bravos, Vikash K Yadav, Novikova, Irina V, Novikova, I. V., Vijaya Kumar Balakrishnan, Ivarsson, Ylva,, Li, Y., Balakrishnan, Vijaya Kumar . K., Rowse, Michael,, Irina V Novikova, Wu, C, G., Yadav, Vikash K, Cheng-Guo Wu, Novikova, Irina, V, Ivarsson, Ylva, Xing, Yongna,, Rowse, Michael, Strack, Stefan,, Ylva Ivarsson, Balakrishnan, Vijaya Kumar,, Strack, Stefan, Stefan Strack, Balakrishnan, Vijaya Kumar, Ivarsson, Y., Bravos, Anastasia Phoebe, Li, Yitong,, Novikova, Irina, V,, Yongna Xing, Rowse, M., Michael Rowse, Wu, Cheng-Guo, Wu, Cheng-Guo,, Yadav, Vikash K.,, Xing, Y., Yitong Li, Bravos, A. P., Strack, S., Bravos, Anastasia Phoebe,, Yadav, Vikash K., Xing, Yongna, Yadav, VK   +41 more
core   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Identification of the New GmJAG1 Transcription Factor Binding Motifs Using DAP-Seq

Plants
Interaction between transcription factors (TFs) and motifs is essential for gene regulation and the subsequent phenotype formation. Soybean (Glycine max) JAGGEED 1 (GmJAG1) is a key TF that controls leaf shape, seed number and flower size.
Jinxing Wang, Zigang Pu, Weiyao Zhang, Mengnan Qu, Lusi Gao, Wenjing Pan, Yanan Sun, Chunxu Fu, Ling Zhang, Mingkun Huang, Yufang Hu   +10 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Systematic Discovery of Short Linear Motifs Decodes Calcineurin Phosphatase Signaling.

, 2020
Short linear motifs (SLiMs) drive dynamic protein-protein interactions essential for signaling, but sequence degeneracy and low binding affinities make them difficult to identify.
Yadav, V.
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source