Results 81 to 90 of about 577,004 (315)
The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome
FEBS Letters, EarlyView.This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley +1 more source
The SLiMDisc server: short, linear motif discovery in proteins
, 2007 Short, linear motifs (SLiMs) play a critical role in many biological processes, particularly in protein-protein interactions. Overrepresentation of convergent occurrences of motifs in proteins with a common attribute (such as similar subcellular location
Davey, Norman E. +5 more
core +1 more source
Impaired O-Glycosylation at Consecutive Threonine TTX Motifs in Mucins Generates Conformationally Restricted Cancer Neoepitopes [PDF]
, 2020 Autoantibody signatures of circulating mucin fragments stem from cancer tissues, and microenvironments are promising biomarkers for cancer diagnosis and therapy.
Yokoi, Yasuhiro +10 more
core +1 more source
“Great Sinners” and Righteous People of L. N. Tolstoy and F. M. Dostoevsky in the Light of A. A. Ukhtomsky’s Ethical Teaching [PDF]
Два века русской классикиThe article proposes a typology of righteous heroes on the material of L. N. Tolstoy’s stories “Father Sergius,” “False Coupon,” “Alyosha the Pot,” and F. M.
Elena A. Fedorova
doaj +1 more source
FEBS Letters, EarlyView.An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley +1 more source
The Most Frequent N-k Line Outages Occur in Motifs That Can Improve Contingency Selection
, 2023 Multiple line outages that occur together show a variety of spatial patterns in the power transmission network. Some of these spatial patterns form network contingency motifs, which we define as the patterns of multiple outages that occur much more ...
Dobson, Ian, Zhou, Kai, Wang, Zhaoyu
core
Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis
FEBS Letters, EarlyView.Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee +7 more
wiley +1 more source
In silico analysis of salt responsive survival associated motifs in rice promoter
, 2014 In stressed condition, several specific transcription factors bind to corresponding regulatory elements or motifs resulting in the expression of appropriate genes, which helps the plant to survive in that condition.
Tabrejee, S. +5 more
core +1 more source
PhytoFrontiersPeppers are a crucial source of nutrition and supplement human diets worldwide. They are of vital importance to the agricultural and food industries, especially in developing countries where growers heavily rely on the production and export of pepper. In
Vishwesh Dayal, Caleb Paslay, Akhtar Ali
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source