Results 81 to 90 of about 1,416,450 (324)
MERP: Motifs enhanced network embedding based on edge reweighting preprocessing
Frontiers in Physics, 2022 Network embedding has attracted a lot of attention in different fields recently. It represents nodes in a network into a low-dimensional and dense space while preserving the structural properties of the network. Some methods (e.g.
Shaoqing Lv +4 more
doaj +1 more source
Evaluation of the Stability of DNA i‐Motifs in the Nuclei of Living Mammalian Cells
Angewandte Chemie, 2018 C‐rich DNA has the capacity to form a tetra‐stranded structure known as an i‐motif. The i‐motifs within genomic DNA have been proposed to contribute to the regulation of DNA transcription.
Š. Džatko +9 more
semanticscholar +1 more source
Structural biology of ferritin nanocages
FEBS Letters, EarlyView.Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley +1 more source
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
The symbolic significance of motifs on selected Asante religious temples
Journal of Aesthetics & Culture, 2015 Asante temples are small edifices built over 100 or 200 years ago to house the shrines of some of the deities of the Asante. They are adorned with beautiful motifs which are a body of knowledge about the culture of the Asante, yet not much scholarly work
Eric Appau Asante +2 more
doaj +1 more source
MoMo: Discovery of statistically significant post-translational modification motifs
bioRxiv, 2018 Motivation Post-translational modifications (PTMs) of proteins are associated with many significant biological functions and can be identified in high throughput using tandem mass spectrometry. Many PTMs are associated with short sequence patterns called
Alice Cheng +3 more
semanticscholar +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
“Great Sinners” and Righteous People of L. N. Tolstoy and F. M. Dostoevsky in the Light of A. A. Ukhtomsky’s Ethical Teaching [PDF]
Два века русской классикиThe article proposes a typology of righteous heroes on the material of L. N. Tolstoy’s stories “Father Sergius,” “False Coupon,” “Alyosha the Pot,” and F. M.
Elena A. Fedorova
doaj +1 more source
eLife, 2016 The nucleolus is a membrane-less organelle formed through liquid-liquid phase separation of its components from the surrounding nucleoplasm. Here, we show that nucleophosmin (NPM1) integrates within the nucleolus via a multi-modal mechanism involving ...
Diana M. Mitrea +8 more
semanticscholar +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source