Results 101 to 110 of about 1,416,450 (324)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
Decoding the Terracotta Tablet Found in Shadyakh Islamic Site of Neishabour [PDF]
نگره, 2015 Symbols have broader functions in the Islamic era in comparison to the pre-Islamic time, the cause of which may be the change of religion and spiritual approach that occurred in the Islamic world.
Abbas Sheikhi, Leila Ghafarpoor
doaj
Detecting Strong Ties Using Network Motifs
, 2017 Detecting strong ties among users in social and information networks is a fundamental operation that can improve performance on a multitude of personalization and ranking tasks. Strong-tie edges are often readily obtained from the social network as users
Kamath, Krishna +3 more
core +1 more source
Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers
Molecular Oncology, EarlyView.This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel +6 more
wiley +1 more source
mBioThe Cryptococcus neoformans capsular extracellular polysaccharide (EPS) plays an essential role in virulence and host immunomodulation. In this study, we analyzed the virulence of four serotype A C.
Samuel Rodrigues Dos Santos Junior +8 more
doaj +1 more source
A Study of the Reflection of Qur'anic Verses in Mihrab Carpets of the Safavid Period [PDF]
قرآن فرهنگ و تمدنAmong the significant decorative elements in Safavid carpets-representing a fusion of Islamic art and culture-is the use of inscriptions containing Qur’anic verses, poetry, or supplications.
Elaheh Panjahbashi, Rana Mohammadzadeh
doaj +1 more source
Subgraphs and network motifs in geometric networks
, 2004 Many real-world networks describe systems in which interactions decay with the distance between nodes. Examples include systems constrained in real space such as transportation and communication networks, as well as systems constrained in abstract spaces
B. A. Huberman +15 more
core +1 more source
Molecular Oncology, EarlyView.Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova +25 more
wiley +1 more source
Combinatorial expression motifs in signaling pathways
Cell GenomicsSummary: In animal cells, molecular pathways often comprise families of variant components, such as ligands or receptors. These pathway components are differentially expressed by different cell types, potentially tailoring pathway function to cell ...
Alejandro A. Granados +2 more
doaj +1 more source