Results 101 to 110 of about 577,004 (315)

Emergent motifs of social justice storytelling as pedagogy

, 2012
Recently, young children have begun to be recognized as active citizens of their world. Stories have a great capacity to explain and explore the world through sensuous and poetic knowing.
Phillips, Louise
core   +1 more source

Motifs

, 2023
This dissertation explores the application of motif discovery in real-world time series, specifically focused on the impact of preprocessing steps on the detection of exact and approximate meaningful motifs (chapters 3 and 4). The results shed light on the discrepancy between commonly held assumptions about normalization and parameter settings and the ...
openaire   +3 more sources

Combinatorial expression motifs in signaling pathways

Cell Genomics
Summary: In animal cells, molecular pathways often comprise families of variant components, such as ligands or receptors. These pathway components are differentially expressed by different cell types, potentially tailoring pathway function to cell ...
Alejandro A. Granados, Nivedita Kanrar, Michael B. Elowitz   +2 more
doaj   +1 more source

Motif patterns in 2D

Theoretical Computer Science, 2008
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Apostolico, A, Parida, L, ROMBO, Simona Ester   +2 more
openaire   +2 more sources

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Ordinal motifs in lattices

Information Sciences
Lattices are a commonly used structure for the representation and analysis of relational and ontological knowledge. In particular, the analysis of these requires a decomposition of a large and high-dimensional lattice into a set of understandably large parts. With the present work we propose /ordinal motifs/ as analytical units of meaning.
Johannes Hirth, Viktoria Horn, Gerd Stumme, Tom Hanika   +3 more
openaire   +2 more sources

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

Structure motivator: a tool for exploring small three-dimensional elements in proteins [PDF]

, 2012
<br>Background: Protein structures incorporate characteristic three-dimensional elements defined by some or all of hydrogen bonding, dihedral angles and amino acid sequence.
Milner-White, E.J., David P Leader, E Milner-White, Leader, D.P.   +3 more
core   +1 more source

In Silico Approach for Prediction of Antifungal Peptides

Frontiers in Microbiology, 2018
This paper describes in silico models developed using a wide range of peptide features for predicting antifungal peptides (AFPs). Our analyses indicate that certain types of residue (e.g., C, G, H, K, R, Y) are more abundant in AFPs.
Piyush Agrawal, Sherry Bhalla, Kumardeep Chaudhary, Rajesh Kumar, Meenu Sharma, Gajendra P. S. Raghava, Gajendra P. S. Raghava   +6 more
doaj   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source