Results 121 to 130 of about 577,004 (315)
Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer
Molecular Oncology, EarlyView.Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley +1 more source
SLIDER: Mining correlated motifs in protein-protein interaction networks
, 2009 —Correlated motif mining (CMM) is the problem to find overrepresented pairs of patterns, called motif pairs, in interacting protein sequences. Algorithmic solutions for CMM thereby provide a computational method for predicting binding sites for protein ...
Boyen, P. +3 more
core
Behavioural motifs of larval Drosophila melanogaster and Caenorhabditis elegans [PDF]
, 2017 I present a novel method for the unsupervised discovery of behavioural motifs in larval Drosophila melanogaster and Caenorhabditis elegans. Most current approaches to behavioural annotation suffer from the requirement of training data.
Szigeti, Balázs
core
MUSICAL COMPOSITION AND ELEMENTARY EXCITATIONS OF THE ENVIRONMENT [PDF]
Interdisciplinary Description of Complex Systems, 2003 During the performance of a musical composition a special human environment comes into being. We aim to interpret the compositions as a specific class of human environment in order to utilise that for description of structure and dynamics of general ...
Damir Pajic +2 more
doaj
MOTIF CERITA RAKYAT SEBAGAI SARANA PENJAGA INTEGRITAS SOSIAL MASYARAKAT ASEAN
Waskita: Jurnal Pendidikan Nilai dan Pembangunan Karakter, 2019 Folklore is a traditional story to convey the noble values of a region to the future generations which are delivered using spoken language. The focus of this study are (1) the motifs and variations of Malin Kundang folklore in various ASEAN countries ...
Lilik Wahyuni
doaj +1 more source
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
Molecular Oncology, EarlyView.We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober +16 more
wiley +1 more source
Computational prediction of splicing regulatory elements shared by Tetrapoda organisms [PDF]
, 2009 Background: auxiliary splicing sequences play an important role in ensuring accurate and efficient splicing by promoting or repressing recognition of authentic splice sites.
Churbanov, Alexander +8 more
core +1 more source
Geometry Concept on the Motifs of Woven Fabric in Kefamenanu Community
Journal of Research and Advances in Mathematics Education, 2019 For the Kefamenanu community, the motif serves as the identity of the person who wears it. Nevertheless, the woven fabric must be present at cultural occasions, welcoming guests, and death ceremonies.
Yohanis Ndapa Deda, Stanislaus Amsikan
doaj +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source