Results 111 to 120 of about 577,004 (315)

T-Reg Comparator: an analysis tool for the comparison of position weight matrices

, 2005
Röpcke S, Grossmann S, Rahmann S, Vingron M. T-Reg Comparator: an analysis tool for the comparison of position weight matrices. Nucleic Acids Research. 2005;33(Web Server):W438-W441.T-Reg Comparator is a novel software tool designed to support research ...
Vingron, Martin, Roepcke, Stefan, Röpcke, Stefan, Grossmann, Steffen, Rahmann, S., Roepcke, S., Grossmann, S., Vingron, M., Rahmann, Sven   +8 more
core   +1 more source

Characterizing Motif Dynamics of Electric Brain Activity Using Symbolic Analysis

Entropy, 2014
Motifs are small recurring circuits of interactions which constitute the backbone of networked systems. Characterizing motif dynamics is therefore key to understanding the functioning of such systems.
Massimiliano Zanin, David Papo
doaj   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Community Detection Using Attribute Homogenous Motif

IEEE Access, 2018
Network community detection with higher-order features has become a hot research topic recently since higher-order features that are captured at the level of small network subgraphs can help to gain new insights into the higher-order organizations of the
Pei-Zhen Li, Ling Huang, Chang-Dong Wang, Dong Huang, Jian-Huang Lai   +4 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

De novo evolution of complex, global and hierarchical gene regulatory mechanisms [PDF]

, 2010
Gene regulatory networks exhibit complex, hierarchical features such as global regulation and network motifs. There is much debate about whether the evolutionary origins of such features are the results of adaptation, or the by-products of non-adaptive ...
Dov J. Stekel, Jenkins, Dafyd J., Dafyd J. Jenkins, Stekel, Dov   +3 more
core   +1 more source

DNA motifs identified by DeepG4.

, 2021
A) Variable importances of DeepG4 cluster motifs, as estimated by random forests. Clustering of DeepG4 kernel motifs was done by RSAT matrix-clustering program to obtain cluster motifs. B) Multidimensional scaling (MDS) of DeepG4 motifs.
Raphael Mourad (11269182), Elissar Nassereddine (11269179), Matthieu Genais (11269176), Vincent Rocher (4544695)   +3 more
core   +1 more source

Borders of Cis-Regulatory DNA Sequences Preferentially Harbor the Divergent Transcription Factor Binding Motifs in the Human Genome

Frontiers in Genetics, 2018
Changes in cis-regulatory DNA sequences and transcription factor (TF) repertoires provide major sources of phenotypic diversity that shape the evolution of gene regulation in eukaryotes.
Jia-Hsin Huang, Ryan Shun-Yuen Kwan, Zing Tsung-Yeh Tsai, Tzu-Chieh Lin, Huai-Kuang Tsai   +4 more
doaj   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Slicing, sampling, and distance-dependent effects affect network measures in simulated cortical circuit structures

Frontiers in Neuroanatomy, 2014
The neuroanatomical connectivity of cortical circuits is believed to follow certain rules, the exact origins of which are still poorly understood. In particular, numerous nonrandom features, such as common neighbor clustering, overrepresentation of ...
Daniel Carl Miner, Jochen eTriesch
doaj   +1 more source