Results 91 to 100 of about 519 (150)
Mutations in Dnaaf1 and Lrrc48 Cause Hydrocephalus, Laterality Defects, and Sinusitis in Mice
G3: Genes, Genomes, Genetics, 2016 We have previously described a forward genetic screen in mice for abnormalities of brain development. Characterization of two hydrocephalus mutants by whole-exome sequencing after whole-genome SNP mapping revealed novel recessive mutations in Dnaaf1 and ...
Seungshin Ha +3 more
doaj +1 more source
Mitochondrial control of ciliary gene expression and structure in striatal neurons
The Journal of Physiology, EarlyView.Abstract figure legend Neurons drive animal behaviour by receiving and transmitting information and require energy, primarily supplied by mitochondria, to function. Additionally, neurons need to sense environmental changes to adapt, a function that is locally played by the primary cilia.
Dogukan H. Ulgen +5 more
wiley +1 more source
The Journal of Physiology, EarlyView.Abstract figure legend Schematic outlining the activation of hypoxia‐sensitive pathways, the influence of hypoxia and associated pathways on the cytoskeleton, and the impact of these on disease progression. Abstract A highly‐regulated and dynamic cytoskeleton is vital for functional cellular physiology and the maintenance of homeostasis.
Darragh Flood, Cormac T. Taylor
wiley +1 more source
Andrology, Volume 14, Issue 6, Page 1535-1551, September 2026.ABSTRACT Background Oligoasthenozoospermia is a leading cause of male infertility and has been increasingly associated with the global surge in obesity and exposure to reproductive toxicants. Despite extensive research on each factor individually, their combined pathological effects remain poorly understood.
Yunlong Yao +12 more
wiley +1 more source
Proliferation associated 2G4 is required for the ciliation of vertebrate motile cilia
Communications BiologyMotile cilia are critical structures that regulate early embryonic development and tissue homeostasis through synchronized ciliary motility. The formation of motile cilia is dependent on precisely controlled sequential processes including the generation,
Moonsup Lee +8 more
doaj +1 more source
A Quarter Century of EHD Protein Research: From Endosomal Recycling to Ciliopathies
Traffic, Volume 27, Issue 3, September 2026.Human EHD protein subcellular localization. ABSTRACT Eps15 homology domain‐containing proteins comprise a conserved family of membrane‐remodeling ATPases that regulate endocytic trafficking, membrane fission, receptor recycling, primary ciliogenesis and membrane dynamics across eukaryotes. Since the initial identification of EHD1 and its Caenorhabditis
Devin Frisby +3 more
wiley +1 more source
Molecular Oncology, Volume 20, Issue 8, Page 1933-1962, August 2026.Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau +36 more
wiley +1 more source
Flexible Dielectric Acoustic Resonator Patch for Tissue Regeneration
Advanced Materials, Volume 38, Issue 43, 3 August 2026.A flexible dielectric acoustic resonator patch enables MHz‐range ultrasound generation through resonance amplification without using piezoelectric materials. Conformal integration on a curved substrate allows efficient acoustic delivery to tissue‐mimicking environments.
Donyoung Kang +7 more
wiley +1 more source
HEATR2 plays a conserved role in assembly of the ciliary motile apparatus.
PLoS Genetics, 2014 Cilia are highly conserved microtubule-based structures that perform a variety of sensory and motility functions during development and adult homeostasis.
Christine P Diggle +23 more
doaj +1 more source
Engineering Reports, Volume 8, Issue 8, August 2026.The current work examines the dynamics of the stagnation point flow of an unsteady hybrid nanofluid (Fe2O3–Cu/H2O) across an inclined porous stretching surface. It considers heat transfer, second‐order slip, electrical field, heat source/sink, mixed convection, and magnetic field effects, as well as linear and nonlinear radiation.
Mazhar Hussain +4 more
wiley +1 more source